Protein Alignment ITM2B and itm2ba

DIOPT Version :10

• Sequence 1: NP_068839.1
• Gene: ITM2B / 9445
• HGNCID: 6174
• Length: 266
• Species: Homo sapiens
• Sequence 2: NP_955940.1
• Gene: itm2ba / 323632
• ZFINID: ZDB-GENE-030131-2352
• Length: 261
• Species: Danio rerio
• Alignment Length: 270
• Identity: 159/270 - (58%)
• Similarity: 212/270 - (78%)
• Gaps: 16/270 - (5%)

Human     1 MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQR-RAWCWCMCFGLAFM 64
            |||:||||||.||:.||:|.   :||| ||.|.      |.:||:.|.|: ||||||||.|||.:
Zfish     1 MVKLTFNSALGQKDLKKEEK---DEAL-IPHDL------DVEDVLRVRQQSRAWCWCMCLGLALI 55

Human    65 LAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADA----PAALYQTIEENIKIFEEE 125
            |:||::||||||:|:.::.:.:|:||:.|.:::..:.:...|.    ||| |:.|||.:::.|:|
Zfish    56 LSGVVVGGAYLYRYYFIEEERMYFCGVNYREENYKMQDSQEDTDMDLPAA-YKRIEEKVRVLEDE 119

Human   126 EVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAG 190
            .||.|::|||:|:|||||:||||||::|||||||.|:||||||||||:||||::.||||:|||||
Zfish   120 GVELINIPVPKFSDSDPADIVHDFNRRLTAYLDLRLNKCYVIPLNTSVVMPPKDFLELLVNIKAG 184

Human   191 TYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFE 255
            ||||||||:.|.|::|.::|::|.||:|||.||..::||||:||||:.|||||||.||..|.|||
Zfish   185 TYLPQSYLVREQMMVTGKVEHVDQLGYFIYGLCRGRDTYKLERRETVLGIQKREALNCHKILHFE 249

Human   256 NKFAVETLIC 265
            |||.||||||
Zfish   250 NKFVVETLIC 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITM2B	NP_068839.1	Necessary for interaction with APP and inhibitor effects on APP processing	102..134		13/35 (37%)
		BRICHOS	137..231	CDD:198107	65/93 (70%)
itm2ba	NP_955940.1	BRICHOS	131..225	CDD:198107	65/93 (70%)