Protein Alignment ITM2B and itm-2

DIOPT Version :10

• Sequence 1: NP_068839.1
• Gene: ITM2B / 9445
• HGNCID: 6174
• Length: 266
• Species: Homo sapiens
• Sequence 2: NP_741791.2
• Gene: itm-2 / 180816
• WormBaseID: WBGene00016106
• Length: 307
• Species: Caenorhabditis elegans
• Alignment Length: 245
• Identity: 61/245 - (24%)
• Similarity: 105/245 - (42%)
• Gaps: 28/245 - (11%)

Human    18 DEPKSGEEALIIP---------PDAVAVDCKDPDDVVPVGQRR-AWCWCMCFGLAFMLAGVILGG 72
            |.||....:...|         |.|.......||....|..|| ..|..:.|.|..:.:.|||..
 Worm    52 DRPKEKRSSSFGPLSIIRLSPSPLARTPSPSPPDYENAVNARRMRRCTKLTFTLISIFSFVILVS 116

Human    73 AYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEF 137
            .:||:...:..  .|..|:.:..:....:.      ..:.:.:.:|::|...:..|  .:.||:|
 Worm   117 FFLYQQGLISV--AYQKGVYHGWNAATFSN------RGMTERLVQNVEINANDSYE--KIDVPKF 171

Human   138 ADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKA---GTYLPQSYLI 199
            ..:.||..:|||.:.|||.:|...::|:|..|:.:.:..||.|:|:|.||..   .....|:.::
 Worm   172 GSNRPAIFLHDFKQNLTAIVDTVGNRCFVKELDRTKIRNPRMLMEMLRNIDVMAPEVAYAQTRVV 236

Human   200 HEHMVITDRIENIDHLGF---FIYRLCHDKETYKLQRRETIKGIQKREAS 246
            .|...:.|.:...|...|   .:.|.|..::||||:::|...  :.|.||
 Worm   237 RETYNVGDELTKADISTFNSTILSRHCAFRQTYKLKKQEAQS--RSRRAS 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITM2B	NP_068839.1	Necessary for interaction with APP and inhibitor effects on APP processing	102..134		3/31 (10%)
		BRICHOS	137..231	CDD:198107	29/99 (29%)
itm-2	NP_741791.2	BRICHOS	171..271	CDD:198107	29/99 (29%)