Protein Alignment ITM2B and Itm2b

DIOPT Version :10

• Sequence 1: NP_068839.1
• Gene: ITM2B / 9445
• HGNCID: 6174
• Length: 266
• Species: Homo sapiens
• Sequence 2: NP_032436.1
• Gene: Itm2b / 16432
• MGIID: 1309517
• Length: 266
• Species: Mus musculus
• Alignment Length: 266
• Identity: 254/266 - (95%)
• Similarity: 261/266 - (98%)
• Gaps: 0/266 - (0%)

Human     1 MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFML 65
            ||||||||||||||||||||||.|||||:||||||||||||.|||||||||||||||||||||||
Mouse     1 MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVAVDCKDPGDVVPVGQRRAWCWCMCFGLAFML 65

Human    66 AGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFI 130
            |||||||||||||||||||||||||:|||||||||||||||||||.|||||||||||||:.||||
Mouse    66 AGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDAVEFI 130

Human   131 SVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQ 195
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   131 SVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQ 195

Human   196 SYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAV 260
            ||||||||||||||||:|:|||||||||||||||||||||||:|||||||||||.||||||||||
Mouse   196 SYLIHEHMVITDRIENVDNLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAV 260

Human   261 ETLICS 266
            ||||||
Mouse   261 ETLICS 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITM2B	NP_068839.1	Necessary for interaction with APP and inhibitor effects on APP processing	102..134		28/31 (90%)
		BRICHOS	137..231	CDD:198107	90/93 (97%)
Itm2b	NP_032436.1	Necessary for interaction with APP and inhibitor effects on APP processing. /evidence=ECO:0000250	102..134		28/31 (90%)
		BRICHOS	137..231	CDD:198107	90/93 (97%)