Protein Alignment MED17 and MED17

DIOPT Version :9

• Sequence 1: NP_004259.3
• Gene: MED17 / 9440
• HGNCID: 2375
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_650686.1
• Gene: MED17 / 42175
• FlyBaseID: FBgn0038578
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 289/675 - (42%)
• Similarity: 425/675 - (62%)
• Gaps: 73/675 - (10%)

Human     6 AVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGS----GSEEEEAAGTEGD 66
            :|.||:|:.||.|:.|:|.||||.|.||.::|::||:.|.|||||:.|    ..||:.||
  Fly     4 SVNISVETTCENQIREIGYDGTELYQPPPTLSESLAKCAARIDFSKTSLDDLKKEEKSAA----- 63

Human    67 AQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVS 131
                    ::||:|.:  ..:||.||||||:|||.|:.||||:|||.||:||.:||:::.|||:.
  Fly    64 --------AAADEDKD--ATQFQESLWPWDAVRNKLKDALTEICVLSDVISIAKDKRYLVLDPLL 118

Human   132 QDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKL 196
            ::|...|   ..:|:.|:||:::.|||:||.|||||..:.:| |.|:...||:.|||||||:|:|
  Fly   119 EEADDTK---PIVQVYSRKKAISQAAQVLLSGAERLRNAHSE-QRNRNVSDFHIELLRLRQNWRL 179

Human   197 RKVGDKILGDLSYRSAGSLFPHHGTFEVIK---------------------NTDLDLDKKIPEDY 240
            :||.:.|:||||||:|||.|...|||||.|                     |..:.|...
  Fly   180 KKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEETGDEDTASSSNSSSSVSGNNGMQLKAS----- 239

Human   241 CPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGT--VNLFKR-PLPKSKPGSPHWQTKLEAAQNVL 302
            ..|.|.:|::|:|.|||||..||   |..||.|  :||... |...::.|.  ||..||.|||||
  Fly   240 SALRVIVPAELQGVAYIKVITQK---DQEDLCTAQLNLMGHGPNITAQVGV--WQKTLEFAQNVL 299

Human   303 LCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCP-ED 366
            .|||:||||:|||:|:::.:||:|:.|||.:...|::||.||||||:.      |.:.:..| .|
  Fly   300 FCKELFAQLAREAIQLQAPIPHVVIGNQIRATLLPNIQLIISLCHSTT------FDSSQPAPIND 358

Human   367 HLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFG--HKRMRLSGPQAFDKNEINSLQSSEGLLE 429
            |.:||||:||.|:||.|.:. |....|||||||.|  .||| |:||.|.|:..:..:..|:.:||
  Fly   359 HDHVLEHSLHQLLREVHYKN-SHHPFPHPASAPLGPTKKRM-LAGPMAADRETLLDMTKSQTILE 421

Human   430 KIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQ 494
            :||.||:|||:|.|....:|:||..::||||.:||:.:|....|.||:.|.:.||:.|.:: .|.
  Fly   422 QIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMNSPTMSCVKINIVTHGYDAIGRT-SLV 485

Human   495 LNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGP 559
            :::....::.:.|||||:.|||:.|||:|.:|.|::.||:..:..||:.|.|.|||.|||:|:|.
  Fly   486 IHVKERSLKCICRDGRVMRLSYEPQELRDLILCQINSHQISCLISLARCMSWTVLSNSNHLGIGK 550

Human   560 IESIGNASAITVASPSGD--YAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPF 622
            :|.:||||:..:|||:.|  .|:.:|..|:...|:.:  .|:..:|...|.::.:..|.:|.|.|
  Fly   551 VEPLGNASSCLLASPNSDRMIAVQIRCDPQIDVKVYI--ARSPRQDFFPSPLVPEKLWENLGGTF 613

Human   623 KEVQWNKMEGRNFVYKMELLMSALS 647
            |||:::|:||::|:.|||.||::|:
  Fly   614 KEVRFDKIEGKSFLNKMEFLMASLT 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED17	NP_004259.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..83		8/35 (23%)
		Med17	<125..432	CDD:401965	143/333 (43%)
MED17	NP_650686.1	Med17	<289..390	CDD:287165	50/101 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159724
Domainoid	1	1.000	216	1.000	Domainoid score	I2705
eggNOG	1	0.900	-	-		E1_KOG4512
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3151
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1425
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49235
OrthoDB	1	1.010	-	-		D414603at33208
OrthoFinder	1	1.000	-	-		FOG0007468
OrthoInspector	1	1.000	-	-		oto91597
orthoMCL	1	0.900	-	-		OOG6_104213
Panther	1	1.100	-	-	LDO	PTHR13114
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2632
SonicParanoid	1	1.000	-	-		X5596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800