Protein Alignment ABCG2 and abcg2a

DIOPT Version :10

• Sequence 1: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Sequence 2: XP_073794813.1
• Gene: abcg2a / 735312
• ZFINID: ZDB-GENE-050517-35
• Length: 644
• Species: Danio rerio
• Alignment Length: 626
• Identity: 396/626 - (63%)
• Similarity: 502/626 - (80%)
• Gaps: 15/626 - (2%)

Human    34 GAVLSFHNICYRVKLKSGFLPCR-KPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARK 97
            ||.:|||||.|.:|:||||  |: |..:|.||..:|||||||||||||.||.||||.||||||||
Zfish    30 GATVSFHNINYSLKMKSGF--CKSKSTKKNILIGLNGIMKPGLNAILGATGSGKSSFLDVLAARK 92

Human    98 DPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERIN 162
            ||:||||:|||:|||:|.||||.||||||||||||||||||||:|||||||..::...||:|::.
Zfish    93 DPAGLSGEVLIDGAPQPPNFKCLSGYVVQDDVVMGTLTVRENLRFSAALRLPKSIKQREKDEKVE 157

Human   163 RVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLL 227
            |:||||||.|||||:||||.||||||||||||:||||||.||.:|||||||||||:||||:||:|
Zfish   158 RLIQELGLSKVADSRVGTQLIRGVSGGERKRTNIGMELIIDPPVLFLDEPTTGLDASTANSVLML 222

Human   228 LKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
            ||:|...|||||.|||||||||::||||||||..|:|::|||||:||.||...||.||.:|||||
Zfish   223 LKKMGNNGRTIILSIHQPRYSIYRLFDSLTLLVGGKLVYHGPAQDALSYFSQIGYTCEPHNNPAD 287

Human   293 FFLDIINGDSTAVALNREEDFKATEIIEP---SKQDKPLIEKLAEIYVNSSFYKETKAELHQLSG 354
            ||||:|||||:||.||:..:    |:::.   |...|.:.::|.|.|..||.:::|.|:|.::..
Zfish   288 FFLDVINGDSSAVTLNKLYE----EVVDQDQLSSSLKGIEDRLVEEYQRSSIFQQTHADLQRIVQ 348

Human   355 GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKND 419
            |:........:.|:|:||||||..||.||:|:||:.|||.|:|||.|.:.|.||:|||:||:..:
Zfish   349 GQDYSTRPKSRTITYSTSFCHQFHWVLKRTFRNLMLNPQTSVAQIGVMIFLALVVGAIFFGVAEN 413

Human   420 STGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRML 484
            |:|||||.|.|||:|||||||||||.|||:.|:|||:|||||||||||.|||.|:|||:|.:|.:
Zfish   414 SSGIQNRMGALFFITTNQCFSSVSAAELFIAERKLFVHEYISGYYRVSVYFLSKILSDILTLRTI 478

Human   485 PSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMM 549
            |::||:|:.|||:||||.|:|||:.:|:::||:|:|::|.|||:|.|:||::|.:.|||.|||||
Zfish   479 PAVIFSCVAYFMIGLKPAAEAFFIFLFSIIMVSYTATAMTLAISADQTVVAIANIFMTISFVFMM 543

Human   550 IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYL 614
            |||||||||.::|:||:||:||||||||.:|||.|||.|..||...|.:| :.|:    :|||:|
Zfish   544 IFSGLLVNLPSVATWLNWLKYFSIPRYGLSALQINEFTGLFFCDNRNNSG-SVCS----SGEEFL 603

Human   615 VKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655
            .:||||.|.||||:||:||..|..|||.||||||.|:||::
Zfish   604 QEQGIDYSAWGLWQNHLALGIMTFIFLCIAYLKLRFIKKFT 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	379/597 (63%)
abcg2a	XP_073794813.1	None