Protein Alignment ABCG2 and wht-2

DIOPT Version :10

• Sequence 1: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_502164.1
• Gene: wht-2 / 178069
• WormBaseID: WBGene00007513
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 644
• Identity: 194/644 - (30%)
• Similarity: 318/644 - (49%)
• Gaps: 72/644 - (11%)

Human    19 GFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPT 82
            |..|:..:.|:| .:...|::|||....: |||         |:||.|::||.||| |.|::|.:
 Worm    17 GAAASMISALEA-VDPVTLTWHNISIHAE-KSG---------KQILENVSGIAKPGQLLALMGAS 70

Human    83 GGGKSSLLDVLAARKDPSGL--SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAA 145
            |.||::||::|.:| :..||  ||.|.:||..........|||..||::.:|||||:|.|...|.
 Worm    71 GAGKTTLLNMLLSR-NLRGLETSGSVKVNGHELGRGITAISGYAQQDELFVGTLTVKEYLDIQAK 134

Human   146 LRLATTMTNHEKNERINRVIQELGLDKVADSKVGT---QFIRGVSGGERKRTSIGMELITDPSIL 207
            ||:  ...:.::..|:..|:.:|||.|..::::||   |  :|:||||.:|.:...||:::||||
 Worm   135 LRV--NGDSEKRRRRVGNVMSQLGLYKCQNTRIGTIGGQ--KGISGGEMRRLTFACELLSNPSIL 195

Human   208 FLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQE 272
            |.|||||||||..|.:|:.:|..::|.|||:|.:||||...::.:||.:..:|.|:..|.|..::
 Worm   196 FCDEPTTGLDSFMAESVVQVLSNLAKSGRTVICTIHQPSSQLYLMFDRVMFMAGGKTAFLGSPRD 260

Human   273 ALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDK--PLIEKLAEI 335
            |:.:||.||:.|....||||..:.                   |..:.|:::||  ..||.:...
 Worm   261 AIQFFEDAGFACPRNFNPADLIIH-------------------TLAVMPNEEDKCRQRIEVIYTK 306

Human   336 YVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQII 400
            :.|||:.:..|..:.:...|::..:       .:.|....|:..:.:||..:...||..:.|::|
 Worm   307 FQNSSYGRTLKFGVEKSDEGQRPSE-------RHKTGILTQIGALLERSAIDTWRNPSLTRAKVI 364

Human   401 VTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFV-VEKKLFIHEYISGYY 464
            ...::||.||.:|......|.||.|..|.||:|.....:|::..:..|: .:..|...||..|.|
 Worm   365 QKSIMGLFIGLLYLQSPLTSIGISNLNGALFYLVCELTYSTIFGILNFLPADFPLVSREYHDGLY 429

Human   465 RVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAA 529
            .|.||::.:.|| .||:.....:|...:.|:|:|................::..|:|:..:.|:.
 Worm   430 SVFSYYVARCLS-YLPLFTADGLIMLLVSYWMVGFSSSITQVLYACLIAFLIEQSSSACGIMISC 493

Human   530 GQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG 594
            ....:.:|..........:.:..||..|:..:.|::||:||.|..||||.|...|::
 Worm   494 ISPSLPIAMSTAGPMLTLLSLTGGLYANVGALPSYISWIQYLSWFRYGFEAFAINQW-------- 550

Human   595 LNATGNNPCNYATCTGEEYLVKQGIDLSPWG-----LWKNHVALACMIVIFLTIAYLKL 648
               :..|..|....|.|    |:...||...     .:.:...::..|:||.||.|..|
 Worm   551 ---SSVNEQNTTIWTDE----KRDSVLSQLSFRAEMFYPDLFIMSAFILIFYTIGYAGL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	183/608 (30%)
wht-2	NP_502164.1	3a01204	44..610	CDD:273361	186/616 (30%)