Protein Alignment KCNK6 and CG42594

DIOPT Version :10

• Sequence 1: NP_004814.1
• Gene: KCNK6 / 9424
• HGNCID: 6281
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Alignment Length: 241
• Identity: 36/241 - (14%)
• Similarity: 71/241 - (29%)
• Gaps: 65/241 - (26%)

Human   451 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVIVKDPTKVMVPPSSMDVTVGESI 515
            |....:.|.|::.:::..::        :.|:.....|:.|..:::|......|:....|..:..
  Fly    88 NNTCYLCEYGSVSLVSRIRT--------SKNYVALKRSSPNPFIREPLGTCPTPNLRLKTCAKGW 144

Human   516 VLPCQVTHDHSLDIVFTWTFNGHLIDFDKDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT 580
            ....:....:.|.|::.....|.|.||                                   :|.
  Fly   145 KFALRYNASYCLKIIYDELATGALQDF-----------------------------------IQA 174

Human   581 SVDKLSVAADLIVRGPPGPPEAVTIDEITDTTAQLS-----------WRPGPDNHS-PITMYVIQ 633
            ..::|.:..:..:.|.....|.:.:..|.|....:.           |..|....| |.|.....
  Fly   175 KAEQLCININSTLSGLESEAERIYVVVIEDQAVAIRNERSIDSRWGVWIDGKHQSSCPTTATGCD 239

Human   634 ARTPFS---------VGWQAVNTVPDLVDGKTFTATVVGLNPWVEY 670
            ....||         .|::.....|:.. |:.|....|.:.|.|:|
  Fly   240 LTKNFSFRDTTLHFKAGYKWATGEPNGA-GRKFCCAYVYITPNVQY 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK6	NP_004814.1	Ion_trans_2	75..146	CDD:462301
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111
		Ion_trans_2	180..256	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..313
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301
		Ion_trans_2	774..846	CDD:462301