Protein Alignment KCNK6 and Shawl

DIOPT Version :10

• Sequence 1: NP_004814.1
• Gene: KCNK6 / 9424
• HGNCID: 6281
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 156
• Identity: 41/156 - (26%)
• Similarity: 61/156 - (39%)
• Gaps: 22/156 - (14%)

Human     1 MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVER 65
            |:|.....|.|.|::...::....:.|    |...||..:.|.:|         :|..|...|..
  Fly   366 MQRMGEYTGLLEAFSIVRIMRLFKLTR----HSPGLRILIHTFKA---------SAKELTLLVFF 417

Human    66 VLAAGRLGRVVLANASGSAN--ASDPAWDFAS---ALFFASTLITTVGYGYTTPLTDAGKAFSIA 125
            ::    ||.|..|:.:..|.  ..:|...|.|   .|::|...:||||||...|.|..|......
  Fly   418 LV----LGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGAL 478

Human   126 FALLGVPTTMLLLTASAQRLSLLLTH 151
            .||.||.|..|.:.......|:..:|
  Fly   479 CALAGVLTIALPVPVIVSNFSMFYSH 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK6	NP_004814.1	Ion_trans_2	75..146	CDD:462301	23/75 (31%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		4/4 (100%)
		Ion_trans_2	180..256	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..313
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	41/156 (26%)