DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNK6 and galene

DIOPT Version :10

Sequence 1:NP_004814.1 Gene:KCNK6 / 9424 HGNCID:6281 Length:313 Species:Homo sapiens
Sequence 2:NP_612084.1 Gene:galene / 38133 FlyBaseID:FBgn0035192 Length:729 Species:Drosophila melanogaster


Alignment Length:281 Identity:51/281 - (18%)
Similarity:79/281 - (28%) Gaps:131/281 - (46%)


- Green bases have known domain annotations that are detailed below.


Human   372 TIVNLSDAGMYQCVAENKHGVIFSSAE---------LSVIAE---------SPDFSRTLLK---- 414
            ||..|:....|:|:.   |...|.|..         ..:|.|         .||||..||.    
  Fly   126 TIFRLAHGASYECLV---HRFGFDSTSQASRSFFTVCKLINEKLSQQLDDPKPDFSPNLLPNCYG 187

Human   415 ---------RVTLVKVGGEVVIECKPKASPRPV---YTW---RKGREILRENERITISEDGNLRI 464
                     :..|:...|.::::....::.|.|   ..|   .|...|.|:.:..:|:|:     
  Fly   188 VVGFGRFEVKGKLLGAKGSILVQALVDSNGRFVDISAGWPSTMKPEAIFRQTKLFSIAEE----- 247

Human   465 INVTKSDAGSYTCIATNHFGTASSTGNVIVKDPTK----VMVPPSSMDVTVGES-------IVLP 518
                                       |:...|||    |:||    ...:|:|       :|.|
  Fly   248 ---------------------------VLSGAPTKLGNGVLVP----RYILGDSCLPLLPWLVTP 281

Human   519 CQVTHD----------------HSLDIVFT------------W----------------TFNGHL 539
            ..:|.|                ||::|.|.            |                ..:..|
  Fly   282 YDLTSDEESFREEFNNVVHTGLHSVEIAFAKVRARWRILDKKWKPETIEFMPFVITTGCLLHNFL 346

Human   540 IDFDKDGDHFERVGGQDSAGD 560
            ::...|.|..|.......|||
  Fly   347 VNSGDDDDSVEECVNGCEAGD 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNK6NP_004814.1 Ion_trans_2 75..146 CDD:462301
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789 106..111
Ion_trans_2 180..256 CDD:462301
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789 214..219
Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8 282..290
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..313
Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8 308..312
galeneNP_612084.1 Ion_trans_2 115..189 CDD:462301 16/65 (25%)
Ion_trans_2 626..706 CDD:462301
Blue background indicates that the domain is not in the aligned region.

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