Protein Alignment OPN4 and Rh6

DIOPT Version :10

• Sequence 1: XP_016872444.1
• Gene: OPN4 / 94233
• HGNCID: 14449
• Length: 539
• Species: Homo sapiens
• Sequence 2: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Alignment Length: 375
• Identity: 129/375 - (34%)
• Similarity: 191/375 - (50%)
• Gaps: 45/375 - (12%)

Human    20 MATPAPPSWWDSSQSSISSLGRLPSISPTAPGT--------WAAAWVPLPTVDVPDHAHYTLGTV 76
            ||:..|||:      :....||..|::.:.|..        | ..|.||..:     ....:|.|
  Fly     1 MASLHPPSF------AYMRDGRNLSLAESVPAEIMHMVDPYW-YQWPPLEPM-----WFGIIGFV 53

Human    77 ILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTS 141
            |.::|...:.||..|:|.|           ..|:.||||:|||::|||.|||:|.||..|....:
  Fly    54 IAILGTMSLAGNFIVMYIF-----------TSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLN 107

Human   142 SLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASK----RRAAFVL 202
            ..|..|:.|...||.|...|:|||..|:.::|.||.|||.||.:     |:|.|    ..|...|
  Fly   108 GFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVK-----GMARKPLTATAAVLRL 167

Human   203 LGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYI 267
            :.||....||:|.|.|||:.|||||.:|:|..||.:.....|:|.::...:|:..|||.||:.|.
  Fly   168 MVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYW 232

Human   268 FIFRAIRETGRALQTFGACKGNGESLWQRQRLQS---ECKMAKIMLLVILLFVLSWAPYSAVALV 329
            .|.:|:....:|::. .|.|.|..||...:..:|   |.|:||:.|..|.|:..:|.||:.:...
  Fly   233 HIMKAVAAHEKAMRE-QAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYA 296

Human   330 AFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCL 379
            ......| |:|..:...:|.|||:|:.|||:|.::||||:..:.:.:|||
  Fly   297 GIFESMH-LSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCL 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPN4	XP_016872444.1	7tmA_Melanopsin	71..372	CDD:320458	113/307 (37%)
		TM helix 1	72..109	CDD:320458	9/36 (25%)
		TM helix 2	116..142	CDD:320458	13/25 (52%)
		TM helix 3	154..184	CDD:320458	15/29 (52%)
		TM helix 4	196..218	CDD:320458	8/21 (38%)
		TM helix 5	243..273	CDD:320458	10/29 (34%)
		TM helix 6	300..330	CDD:320458	11/32 (34%)
		TM helix 7	340..365	CDD:320458	10/24 (42%)
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	113/307 (37%)
		TM helix 1	49..75	CDD:320207	9/36 (25%)
		TM helix 2	82..108	CDD:320207	13/25 (52%)
		TM helix 3	120..150	CDD:320207	15/29 (52%)
		TM helix 4	161..181	CDD:320207	7/19 (37%)
		TM helix 5	208..237	CDD:320207	10/28 (36%)
		TM helix 6	267..297	CDD:320207	10/29 (34%)
		TM helix 7	306..331	CDD:320207	10/24 (42%)