Protein Alignment OPN4 and Rh4

DIOPT Version :10

• Sequence 1: XP_016872444.1
• Gene: OPN4 / 94233
• HGNCID: 14449
• Length: 539
• Species: Homo sapiens
• Sequence 2: NP_476701.1
• Gene: Rh4 / 39887
• FlyBaseID: FBgn0003250
• Length: 378
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 127/386 - (32%)
• Similarity: 191/386 - (49%)
• Gaps: 53/386 - (13%)

Human    16 EPSCMATPAP--PSWWDSSQSSISSLGRLPSISPT----APGTWAAAWVPLPTVDVPDHAHYTLG 74
            ||.|.|:..|  |....|....:..||.  ::.|.    .|..|      |..::.|...||.||
  Fly     2 EPLCNASEPPLRPEARSSGNGDLQFLGW--NVPPDQIQYIPEHW------LTQLEPPASMHYMLG 58

Human    75 TVILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFF 139
            ...:.:.....:||..||:.|           ..|:|||||:|||::||||.|.:|.. :||:|.
  Fly    59 VFYIFLFCASTVGNGMVIWIF-----------STSKSLRTPSNMFVLNLAVFDLIMCL-KAPIFI 111

Human   140 TSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPL---ATFGVASKRRAAFV 201
            .:|.::.:..|.|.|:.:|..|:..||.:.:|..||..|||.|||:|:   .||     .:|..:
  Fly   112 YNSFHRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNMTF-----TKAVIM 171

Human   202 LLGVWLYALAWSLPPFFG-WSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYC 265
            .:.:|||...|.:.|... |..:||||.|||||:||:|.....|.:...:..|.|..|.|:|:|.
  Fly   172 NIIIWLYCTPWVVLPLTQFWDRFVPEGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYY 236

Human   266 YIFIF-------RAIRETGRALQTFGACKGNGESL---WQRQRLQSECKMAKIMLLVILLFVLSW 320
            |..|.       :|:||..:        |.|.|||   ..:.:..:|.::||..:.:..||.:||
  Fly   237 YSQIVGHVFSHEKALREQAK--------KMNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSW 293

Human   321 APYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGV 381
            .||..::|:...|...:|||..:.:||...|..|..:|.:|||:||:||:.:.:..|.|||
  Fly   294 TPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGV 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPN4	XP_016872444.1	7tmA_Melanopsin	71..372	CDD:320458	108/314 (34%)
		TM helix 1	72..109	CDD:320458	7/36 (19%)
		TM helix 2	116..142	CDD:320458	12/25 (48%)
		TM helix 3	154..184	CDD:320458	12/29 (41%)
		TM helix 4	196..218	CDD:320458	6/21 (29%)
		TM helix 5	243..273	CDD:320458	9/36 (25%)
		TM helix 6	300..330	CDD:320458	10/29 (34%)
		TM helix 7	340..365	CDD:320458	9/24 (38%)
Rh4	NP_476701.1	7tmA_photoreceptors_insect	55..345	CDD:320207	108/314 (34%)
		TM helix 1	56..82	CDD:320207	7/36 (19%)
		TM helix 2	89..114	CDD:320207	12/25 (48%)
		TM helix 3	126..156	CDD:320207	12/29 (41%)
		TM helix 4	166..186	CDD:320207	5/19 (26%)
		TM helix 5	214..243	CDD:320207	9/28 (32%)
		TM helix 6	273..303	CDD:320207	10/29 (34%)
		TM helix 7	313..338	CDD:320207	9/24 (38%)