Protein Alignment OPN4 and Rh7

DIOPT Version :10

• Sequence 1: XP_016872444.1
• Gene: OPN4 / 94233
• HGNCID: 14449
• Length: 539
• Species: Homo sapiens
• Sequence 2: NP_524035.2
• Gene: Rh7 / 39389
• FlyBaseID: FBgn0036260
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 421
• Identity: 125/421 - (29%)
• Similarity: 202/421 - (47%)
• Gaps: 63/421 - (14%)

Human    30 DSSQSSISSLGRLPS------------ISPTAPGTWAAAWVPLPTVDVPDHAHY-TLGTVILLVG 81
            ||..:.:|:....||            |:...|     .|:..   :.|..:.: .:..:..|:.
  Fly    71 DSVSTGLSNYSNYPSYIHYRDKYDLSYIAKVNP-----FWLQF---EPPKSSTFLIMAALYCLIS 127

Human    82 LTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQ 146
            :.|.:||..||:.|.           ..:|||||||:.::|||:.|||| ..:.|:...:::.:.
  Fly   128 VVGCVGNAFVIFMFA-----------NRKSLRTPANILVMNLAICDFLM-LIKCPIAIYNNIKEG 180

Human   147 WLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALA 211
            ...|:..|..|.|.|.|.|..::.||||||||||.|:..||......|:.|:..::|.:|.|:..
  Fly   181 PALGDIACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFL 245

Human   212 WSLPPF--FGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIR 274
            :::.|.  .|.|.|||||.||:||:||::.....|.:..|.....:.:||..|:|.|.:|.:.:.
  Fly   246 FAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCIPLTSIVYSYFYILKVVF 310

Human   275 ETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLT 339
            ...| :|:            .:.:.::|.|:|.|:..:|.|:.|:|:||:.||::...|....:|
  Fly   311 TASR-IQS------------NKDKAKTEQKLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHIT 362

Human   340 PYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTL 404
            |..|.:||:..|.:|..:|.:||.|||::||.:.......|||    ||.|....||.:..||:.
  Fly   363 PLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVL----RRVSTTRSSYMTRSRSSF 423

Human   405 TSHTSNLSWISIRRRQESLGSESEVGWTHME 435
            |           .|.:.|...|..:|...||
  Fly   424 T-----------HRLRTSTTGEGGMGDHRME 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPN4	XP_016872444.1	7tmA_Melanopsin	71..372	CDD:320458	99/303 (33%)
		TM helix 1	72..109	CDD:320458	7/36 (19%)
		TM helix 2	116..142	CDD:320458	10/25 (40%)
		TM helix 3	154..184	CDD:320458	17/29 (59%)
		TM helix 4	196..218	CDD:320458	5/23 (22%)
		TM helix 5	243..273	CDD:320458	8/29 (28%)
		TM helix 6	300..330	CDD:320458	12/29 (41%)
		TM helix 7	340..365	CDD:320458	9/24 (38%)
Rh7	NP_524035.2	7tm_GPCRs	118..395	CDD:475119	99/301 (33%)
		TM helix 1	119..143	CDD:320207	7/34 (21%)
		TM helix 2	152..173	CDD:320207	9/21 (43%)
		TM helix 3	189..211	CDD:320207	10/21 (48%)
		TM helix 4	234..250	CDD:320207	3/15 (20%)
		TM helix 5	280..303	CDD:320207	6/22 (27%)
		TM helix 6	329..351	CDD:320207	9/21 (43%)
		TM helix 7	363..388	CDD:320207	9/24 (38%)