Protein Alignment NTN1 and LanB1

DIOPT Version :10

• Sequence 1: NP_004813.2
• Gene: NTN1 / 9423
• HGNCID: 8029
• Length: 604
• Species: Homo sapiens
• Sequence 2: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 161/520 - (30%)
• Similarity: 244/520 - (46%)
• Gaps: 93/520 - (17%)

Human    40 PCSDENGHPRRCIPDFVNAAFGKDVRV--SSTCG-RPPARYCVVSERGEERLRSCHLCNA----- 96
            ||...:     |.|...|...|::.|:  ||||| ..|.|:|::|...:::   |.||:.
  Fly    48 PCERSS-----CYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKK---CFLCDTREETK 104

Human    97 SDPKKAHPPAFLTDLNNP-HNL-TCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESM 159
            .||.|.|....:.....| .|: |.|||||..:   |.|:.|.|..:|..|::.:.|.:.||.:|
  Fly   105 HDPYKNHRIGQIIYKTKPGTNIPTWWQSENGKE---NATIQLDLEAEFHFTHLIITFTTFRPAAM 166

Human   160 AIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLD 224
            .|.:|.|:|:||..:::::..|::.:   ...|...:|..:.:||..::::.|...|.:.|..|.
  Fly   167 YIERSFDFGQTWHIYRYFAYDCKESF---PGVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLP 228

Human   225 GRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELA-RDSYFYAVSDLQVGGRCKCN 288
            ...:..| ..:..:|:.:..|::|:..::||..|| |..||.|. .:.|:|.:|::.|.|.|.|.
  Fly   229 PNINVTD-PYAEHVQNQLKMTNLRIQMTKLHKLGD-NLLDSRLENEEKYYYGISNMVVRGSCSCY 291

Human   289 GHAARCV--------RDRDDSLV---CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACN 342
            |||::|:        .|.:|.:|   |:|.|||.|..|:.|:.|..|.||:.|..::.|.|..|.
  Fly   292 GHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCE 356

Human   343 CNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCH 407
            ||.||..|.|:..::..||..|||||.||.|||.|:||..|...:|||..:.||..:.|:.|||.
  Fly   357 CNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCD 421

Human   408 PVGAAGK-TCNQ--------TTGQCPCKDGVTGITCNRCAKGY--QQSRSP--IAPCIKIPVA-- 457
            |.|::.. .|:.        ..|.|.||..|||..||:|..||  .||.:|  ..||...|:.
  Fly   422 PQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL 486

Human   458 ---------------------------PPTTAASSVEEPEDC-----------DSYCKASKGKLK 484
                                       |.|...|  |.||.|           |:||....|:.:
  Fly   487 NNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLS--ESPEGCSLCNCDAGGSYDNYCDVISGQCR 549

Human   485  484
              Fly   550  549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NTN1	NP_004813.2	LamNT	46..283	CDD:214532	70/247 (28%)
		EGF_Lam	284..329	CDD:238012	21/55 (38%)
		Laminin_EGF	341..401	CDD:395007	28/59 (47%)
		Laminin_EGF	404..>441	CDD:395007	16/45 (36%)
		NTR_netrin-1_like	487..601	CDD:239634
		Cell attachment site. /evidence=ECO:0000255	530..532
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653	70/242 (29%)
		EGF_Lam	287..343	CDD:238012	21/55 (38%)
		Laminin_EGF	355..415	CDD:395007	28/59 (47%)
		Laminin_EGF	418..475	CDD:395007	21/56 (38%)
		EGF_Lam	477..526	CDD:238012	9/50 (18%)
		EGF_Lam	529..567	CDD:214543	4/21 (19%)
		EGF_Lam	789..834	CDD:214543
		Laminin_EGF	837..885	CDD:395007
		Laminin_EGF	883..930	CDD:395007
		Laminin_EGF	933..988	CDD:395007
		Laminin_EGF	991..1035	CDD:395007
		Laminin_EGF	1043..1091	CDD:395007
		Laminin_EGF	1094..1142	CDD:395007
		Laminin_EGF	1142..1190	CDD:395007
		Mplasa_alph_rch	1228..>1771	CDD:275316
		cc_DmLAMB1-like_C	1717..1786	CDD:411973