Protein Alignment HAND1 and twi

DIOPT Version :10

• Sequence 1: NP_004812.1
• Gene: HAND1 / 9421
• HGNCID: 4807
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 180
• Identity: 60/180 - (33%)
• Similarity: 89/180 - (49%)
• Gaps: 24/180 - (13%)

Human    46 LLSPADAAPDFPAGGPPPAAAAAATAY-GPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTES 109
            ::|||..|.|..||.....:.|...|: .|..|..:.|.:.|.. .....::.....:||:||:|
  Fly   314 VMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEET-DEFSNQRVMANVRERQRTQS 377

Human   110 INSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL---------AKDAQSGDPEAF--- 162
            :|.||..|::.||.:|:| |||||:||:|||.||.:|..:|         |.:|| |.|.|:
  Fly   378 LNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQ-GSPSAYGSA 440

Human   163 KAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALE 212
            .:.|..|..|.|:..|. |::..|.|  :.|.||     ..:...||.:|
  Fly   441 SSLLSAAANGAEADLKC-LRKANGAP--IIPPEK-----LSYLFGVWRME 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..109		14/56 (25%)
		bHLH_TS_HAND1	94..153	CDD:381522	28/67 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..198		11/31 (35%)
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	27/58 (47%)