DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HAND1 and CG33557

DIOPT Version :9

Sequence 1:	NP_004812.1	Gene:	HAND1 / 9421	HGNCID:	4807	Length:	215	Species:	Homo sapiens
Sequence 2:	NP_001014730.1	Gene:	CG33557 / 3346145	FlyBaseID:	FBgn0053557	Length:	150	Species:	Drosophila melanogaster

Alignment Length:	114	Identity:	44/114 - (38%)
Similarity:	63/114 - (55%)	Gaps:	11/114 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    42 FQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQ--SPGRLEALGGRLGRRKGSGPK--- 101
            |.::|:  |..|.|..:.|  .|:.:.|.|...|::.||  :||..|..|..  ||:....|
  Fly    10 FSNYLM--AVFAQDSNSSG--SASGSGAAADSEDSQIGQEANPGGQENQGNH--RRRPPRQKINA 68

Human   102 KERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL 150
            :||.||.::|||:..||..||..|.:.|||||:.:|||:|||.:|...|
  Fly    69 RERYRTFNVNSAYEALRNLIPTEPMNRKLSKIEIIRLASSYITHLSSTL 117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..109		20/60 (33%)
		bHLH_TS_HAND1	94..153	CDD:381522	28/60 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..198
CG33557	NP_001014730.1	HLH	67..119	CDD:197674	25/51 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740