DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX23 and ddx23

DIOPT Version :9

Sequence 1:	NP_004809.2	Gene:	DDX23 / 9416	HGNCID:	17347	Length:	820	Species:	Homo sapiens
Sequence 2:	NP_956176.1	Gene:	ddx23 / 334283	ZFINID:	ZDB-GENE-030131-6215	Length:	807	Species:	Danio rerio

Alignment Length:	822	Identity:	700/822 - (85%)
Similarity:	762/822 - (92%)	Gaps:	17/822 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGELADKKDRD-ASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSR 64
            |||: ::|||.| |...:|.|||||:    |.|:||||.||.::|||||||:|:      |||||
Zfish     1 MAGD-SEKKDLDSAGKERESRKRSRS----RSRERDRKGSPGRERKRHRSRERK------RSRSR 54

Human    65 SKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPG-RGKDFKSRKDRDSKKDE 128
            |||.:|:||.|:::||  |||::|||:|::|  ||||||.:.|.|.. :.||.|.::::|.||:|
Zfish    55 SKSPDRDRRLKDKDRD--RDRSRKDRERERD--RRDKDRSKKSRSASPKSKDLKLKREKDVKKEE 115

Human   129 EDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERK 193
            |:|...||.|.|||||||||||||||||||:|||||||:||||||:|||:|..|||:|.|:||||
Zfish   116 EEEAEKKKDKVQPLSLEELLAKKKAEEEAESKPKFLSKSEREAEAIKRREQVAEERRRQLDEERK 180

Human   194 KRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGI 258
            ||:.|||:|||||||||||||||||||||||.|||:|::.||||||||||.|||.|||||||||:
Zfish   181 KRRVFQDIGRKMLEDPQERERRERRERMERENNGNDDDDERQKIREEKDKGKELVAIKERYLGGM 245

Human   259 KKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDL 323
            ||||||||||||||||||||||||||||||:|||:|||.|.|||||||||||||||:||||||||
Zfish   246 KKRRRTRHLNDRKFVFEWDASEDTSIDYNPIYKEKHQVHLYGRGFIAGIDLKQQKRDQSRFYGDL 310

Human   324 MEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPN 388
            ||||||.|||||||.||:|:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   311 MEKRRTNEEKEQEEQRLKKVRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPN 375

Human   389 PIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWI 453
            |||:||:.||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||
Zfish   376 PIRNWKEYSLPPHILEVIEKCGYKDPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWI 440

Human   454 TTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMG 518
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   441 TTLPKIDRIEDSDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMG 505

Human   519 CEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAE 583
            ||||||||||||||||||||||||||||||||||||||||||||||||||::||:|||||||:||
Zfish   506 CEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEYIPVTNQKPDTDDAE 570

Human   584 DPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSE 648
            |||||:.|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Zfish   571 DPEKMMQNFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVILMSE 635

Human   649 SEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAG 713
            .|||||||.:|..||:|||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   636 GEKRKKLLEVLASGFEPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAG 700

Human   714 AKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYE 778
            |||||||||||||||||||||||:|||||||||||||||||||||||||||:||||||||:|||:
Zfish   701 AKDILVATDVAGRGIDIQDVSMVLNYDMAKNIEDYIHRIGRTGRAGKSGVAMTFLTKEDSSVFYD 765

Human   779 LKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA 820
            |||||||||||:||||||||||||||||||||||||||||||
Zfish   766 LKQAILESPVSTCPPELANHPDAQHKPGTILTKKRREETIFA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX23	NP_004809.2	RS domain	1..221		140/221 (63%)
		PTZ00121	<4..>351	CDD:173412	250/348 (72%)
		SF-CC1	80..>210	CDD:273721	86/130 (66%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	391..419		22/27 (81%)
		DEADc_DDX23	402..628	CDD:350703	216/225 (96%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	549..552		2/2 (100%)
		SF2_C_DEAD	639..768	CDD:350174	119/128 (93%)
ddx23	NP_956176.1	DEADc	380..616	CDD:238167	224/235 (95%)
		DEXDc	393..629	CDD:214692	226/235 (96%)
		Helicase_C	637..746	CDD:278689	102/108 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344572
Domainoid	1	1.000	619	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3542
Inparanoid	1	1.050	1389	1.000	Inparanoid score	I1151
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55082
OrthoDB	1	1.010	-	-		D126329at7742
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto45848
orthoMCL	1	0.900	-	-		OOG6_102378
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R991
SonicParanoid	1	1.000	-	-		X3074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300