Protein Alignment ORMDL3 and ORM1

DIOPT Version :10

• Sequence 1: NP_644809.1
• Gene: ORMDL3 / 94103
• HGNCID: 16038
• Length: 153
• Species: Homo sapiens
• Sequence 2: NP_011552.1
• Gene: ORM1 / 852926
• SGDID: S000003270
• Length: 222
• Species: Saccharomyces cerevisiae
• Alignment Length: 138
• Identity: 52/138 - (37%)
• Similarity: 77/138 - (55%)
• Gaps: 2/138 - (1%)

Human    11 NPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHTVKGTPFETP 75
            |.|...::.||.|:.:|:.|.||.:.....|.|:....|||||:.:.:|.|:..|.:|||||:.
Yeast    74 NMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDF- 137

Human    76 DQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNT-VSLMSVLIPKL 139
            :.|....||.|||:|....:|.|||||...||.|:.:::.|..||...|..|. ::....::|||
Yeast   138 NGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKL 202

Human   140 PQLHGVRI 147
            |..|.:||
Yeast   203 PVTHRLRI 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORMDL3	NP_644809.1	Important for ceramide level-sensing. /evidence=ECO:0000269|PubMed:37308477	1..17		2/5 (40%)
		ORMDL	11..146	CDD:461151	50/135 (37%)
ORM1	NP_011552.1	COG5081	42..222	CDD:227413	52/138 (38%)