Protein Alignment ORMDL3 and ORM2

DIOPT Version :10

• Sequence 1: NP_644809.1
• Gene: ORMDL3 / 94103
• HGNCID: 16038
• Length: 153
• Species: Homo sapiens
• Sequence 2: NP_013454.1
• Gene: ORM2 / 851064
• SGDID: S000004342
• Length: 216
• Species: Saccharomyces cerevisiae
• Alignment Length: 139
• Identity: 55/139 - (39%)
• Similarity: 83/139 - (59%)
• Gaps: 5/139 - (3%)

Human    11 NPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPV-VWTLTNLIHNMGMYIFLHTVKGTPFET 74
            |.|...::.||.||.:::.|.||.: ..|: |.|.|. .|||||:.:.:|.||..|.||||||:.
Yeast    69 NMNATWVDQRGAWLIHIVVIVLLRL-FYSL-FGSTPKWTWTLTNMTYIIGFYIMFHLVKGTPFDF 131

Human    75 PDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLN-TVSLMSVLIPK 138
             :.|....||.|||::....:|.:||||.|.||||:.:::.|.:.|...|:.| .|:::..::||
Yeast   132 -NGGAYDNLTMWEQINDETLYTPTRKFLLIVPIVLFLISNQYYRNDMTLFLSNLAVTVLIGVVPK 195

Human   139 LPQLHGVRI 147
            |...|.:||
Yeast   196 LGITHRLRI 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORMDL3	NP_644809.1	Important for ceramide level-sensing. /evidence=ECO:0000269|PubMed:37308477	1..17		2/5 (40%)
		ORMDL	11..146	CDD:461151	53/136 (39%)
ORM2	NP_013454.1	COG5081	37..216	CDD:227413	55/139 (40%)