Protein Alignment ORMDL3 and ormdl2

DIOPT Version :10

• Sequence 1: NP_644809.1
• Gene: ORMDL3 / 94103
• HGNCID: 16038
• Length: 153
• Species: Homo sapiens
• Sequence 2: NP_001016075.1
• Gene: ormdl2 / 548829
• XenbaseID: XB-GENE-1001977
• Length: 153
• Species: Xenopus tropicalis
• Alignment Length: 153
• Identity: 127/153 - (83%)
• Similarity: 142/153 - (92%)
• Gaps: 0/153 - (0%)

Human     1 MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLH 65
            ||||.|||||||||||:|||||||:||:.:|.|||:|||.||.||||||||||:|||:.||:|||
 Frog     1 MNVGVAHSEVNPNTRVLNSRGIWLAYVILVGFLHIILLSFPFFSVPVVWTLTNVIHNLVMYLFLH 65

Human    66 TVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVS 130
            |||||||||||||||||||||||||||:|||:|||||||:|||||.|.|||||||..||::||||
 Frog    66 TVKGTPFETPDQGKARLLTHWEQMDYGIQFTSSRKFLTISPIVLYLLASFYTKYDPAHFLINTVS 130

Human   131 LMSVLIPKLPQLHGVRIFGINKY 153
            |:|||:|||||.|||||||||||
 Frog   131 LLSVLLPKLPQFHGVRIFGINKY 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORMDL3	NP_644809.1	Important for ceramide level-sensing. /evidence=ECO:0000269|PubMed:37308477	1..17		14/15 (93%)
		ORMDL	11..146	CDD:461151	109/134 (81%)
ormdl2	NP_001016075.1	ORMDL	11..146	CDD:461151	109/134 (81%)