Protein Alignment ORMDL3 and ORMDL

DIOPT Version :10

• Sequence 1: NP_644809.1
• Gene: ORMDL3 / 94103
• HGNCID: 16038
• Length: 153
• Species: Homo sapiens
• Sequence 2: NP_730669.1
• Gene: ORMDL / 40404
• FlyBaseID: FBgn0037110
• Length: 154
• Species: Drosophila melanogaster
• Alignment Length: 152
• Identity: 76/152 - (50%)
• Similarity: 106/152 - (69%)
• Gaps: 0/152 - (0%)

Human     2 NVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHT 66
            ::...|.|.|||:..:::||.||:|:|.:..:|::.||:||||:|..||.|||:||.....|||.
  Fly     3 SIAGGHGEANPNSSWLSARGFWLAYLLGLLSVHLLFLSVPFVSIPWAWTATNLLHNAAHLYFLHV 67

Human    67 VKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSL 131
            :||.|:.:.:...:|..|||||:|.|||.|.:|||||..||||:.||..||:.:..||:.|.:||
  Fly    68 IKGAPWLSTENDPSRRWTHWEQIDDGVQMTTTRKFLTAVPIVLFLLTCLYTRNNTEHFIPNFISL 132

Human   132 MSVLIPKLPQLHGVRIFGINKY 153
            :.|.:|||||.||||:|.||||
  Fly   133 VVVTLPKLPQFHGVRLFNINKY 154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORMDL3	NP_644809.1	Important for ceramide level-sensing. /evidence=ECO:0000269|PubMed:37308477	1..17		5/14 (36%)
		ORMDL	11..146	CDD:461151	67/134 (50%)
ORMDL	NP_730669.1	ORMDL	12..147	CDD:461151	67/134 (50%)