DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PEX16 and Pex16

DIOPT Version :9

Sequence 1:	NP_476515.2	Gene:	PEX16 / 9409	HGNCID:	8857	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_649252.1	Gene:	Pex16 / 40293	FlyBaseID:	FBgn0037019	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	119/360 - (33%)
Similarity:	196/360 - (54%)	Gaps:	43/360 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEKLRLLGLRYQEYVTRHPAATAQLETAVRGFSYLLAGRFADSHELSELVYSASNLLVLLNDGIL 65
            |:.|:.:...|:.:|.::|......||..:..||.:|||.:.|:.:|||||:.||:||..||.|:
  Fly     1 MDTLKGMLKAYEAWVGKNPDVVGDFETTAKWVSYFIAGRISSSNVVSELVYTLSNMLVFYNDRII 65

Human    66 RK----------ELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALVQLAK 120
            .|          .|:.||     ..:|...|:.||..|||:|:.|.:::|:.|:||||||:|..|
  Fly    66 EKARNSEENSVIHLQSKL-----CYRLKVTLTTLEYSEVFIEISARRLFGQSGKWLVIALIQAFK 125

Human   121 AVLRMLLLLWFKAGLQTSPPIVPLDRETQAQPPDGDHSPGN--------HEQSYVGKRSNRVVRT 177
            |..|..:|....:.:.|||||..|:|..:.:...||....:        |..::..|||.||:|.
  Fly   126 AAGRFFILKHSTSDIITSPPIAALNRRAKQRKNSGDGVASSTNDLLQSQHSITFQLKRSGRVIRK 190

Human   178 LQNTPSLHSRHWGAPQQREGRQQQHHEELSATPTPLGLQETIAEFLYIARPLLHLLSLGLWGQRS 242
            ::..|.|        |.|:.:....:.|.:.|..|..|.:  ||:|||::||:||:::||:|:||
  Fly   191 VEGAPPL--------QYRDFKLHIDNNEAAKTQIPRKLLQ--AEYLYISKPLIHLVAMGLFGRRS 245

Human   243 WKPWLLAGVVDVTSLSLLSDRKGL-TRRERRELRRRTILLLYYLLRSPFYDRFSEARILFLLQLL 306
            ||.:::|..:|:.|:.|....:.| :::::.||.||.|.::|:|:||||||.|:::|:..:|..:
  Fly   246 WKQYMVALSIDLYSIHLYRQHRDLMSKQQKLELSRRCINIMYFLVRSPFYDSFTKSRLERILDFV 310

Human   307 ADHVPGVGLVTTSQRAASPCLPARPHTQPWSPPAF 341
            |..||...:|..         |.:.:...|....|
  Fly   311 ATSVPIAKVVAK---------PLKDYIPTWQSTYF 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEX16	NP_476515.2	Pex16	10..317	CDD:400777	113/325 (35%)
		Required for peroxisomal location. /evidence=ECO:0000269\|PubMed:11390669	66..81		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..171		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..210		4/25 (16%)
Pex16	NP_649252.1	Pex16	11..333	CDD:285774	116/345 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155359
Domainoid	1	1.000	210	1.000	Domainoid score	I2834
eggNOG	1	0.900	-	-		E1_KOG4546
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3537
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3549
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58411
OrthoDB	1	1.010	-	-		D344611at33208
OrthoFinder	1	1.000	-	-		FOG0006249
OrthoInspector	1	1.000	-	-		oto90457
orthoMCL	1	0.900	-	-		OOG6_103805
Panther	1	1.100	-	-	LDO	PTHR13299
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5562
SonicParanoid	1	1.000	-	-		X5194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800