DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZRANB2 and zranb2

DIOPT Version :9

Sequence 1:	NP_976225.1	Gene:	ZRANB2 / 9406	HGNCID:	13058	Length:	330	Species:	Homo sapiens
Sequence 2:	XP_017211949.1	Gene:	zranb2 / 406716	ZFINID:	ZDB-GENE-040426-2743	Length:	324	Species:	Danio rerio

Alignment Length:	321	Identity:	233/321 - (72%)
Similarity:	253/321 - (78%)	Gaps:	35/321 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFS 65
            ||.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MSGKSFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFS 65

Human    66 ANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRK 130
            |||||||||.||||||||||||||||||||||||||||||||||||:.|.||||||||||||||.
Zfish    66 ANDWQCKTCGNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENLVYNEREESDGEYDEFGRI 130

Human   131 KKKYRGKAVGPASIL---KEVEDKESEGEEEDEDEDLSKYKL--------DEDEDEDDADLSKYN 184
            |||:|||....:...   |:|:..:.|.:::|||.|||||||        |:|:||||||||||:
Zfish   131 KKKFRGKTKKDSDKKEEPKKVDQDDEEEDDDDEDGDLSKYKLDDDDEDDDDDDDDEDDADLSKYD 195

Human   185 LDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERS 249
            ||     |.::||.       |.|..||||||||| |||||||||||||||||:|||||.
Zfish   196 LD-----DGDEKKG-------SHSGSSRSSSRSSS-SSSRSRSRSRSRSSSSSRSRSRSR----- 242

Human   250 RSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPER 310
                |||||||||.:||:|.:||| .|.|||||..:|||||||||.| |||||.||.|.||
Zfish   243 ----SKSRSSSRSGKGSASSKKRS-RSPSSSPEGGQKRSRSRSSSGG-RKKRRARSHSSER 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZRANB2	NP_976225.1	ZnF_RBZ	11..35	CDD:197784	23/23 (100%)
		RanBP2-type Zn finger	13..34	CDD:275376	20/20 (100%)
		ZnF_RBZ	67..91	CDD:197784	22/23 (96%)
		RanBP2-type Zn finger	69..88	CDD:275376	17/18 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..330		123/205 (60%)
		Required for nuclear targeting	151..324		102/168 (61%)
zranb2	XP_017211949.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324583
Domainoid	1	1.000	242	1.000	Domainoid score	I10109
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135921
Inparanoid	1	1.050	438	1.000	Inparanoid score	I7365
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG60166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007371
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106338
Panther	1	1.100	-	-	LDO	PTHR12999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3341
SonicParanoid	1	1.000	-	-		X5493
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.290