DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPXN and ey

DIOPT Version :9

Sequence 1:	NP_001137467.1	Gene:	LPXN / 9404	HGNCID:	14061	Length:	391	Species:	Homo sapiens
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	216	Identity:	41/216 - (18%)
Similarity:	61/216 - (28%)	Gaps:	76/216 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    18 RSTLQDSDEYSNPAPLPLD-QHSRKETNLDETSEILSIQDNTSPLPAQLVYTTNIQELNVYSEAQ 81
            |.||..|.:....| .||: ..|...:|..|.||..:|.:             .::.||....|
  Fly   265 RGTLSSSTDLMQTA-TPLNSSESGGASNSGEGSEQEAIYE-------------KLRLLNTQHAA- 314

Human    82 EPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQD 146
                .|.|.:.:.||.|                 ......||..:..|...:......|:|..|
  Fly   315 ----GPGPLEPARAAPL-----------------VGQSPNHLGTRSSHPQLVHGNHQALQQHQQ- 357

Human   147 LGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQL 211
                                       |||.|.|:..:.....:...|      ::..||
  Fly   358 ---------------------------QSWPPRHYSGSWYPTSLSEIP------ISSAPN----- 384

Human   212 FSPRCAYCAAPILDKVLTAMN 232
            .:...||.:.|.|...|:..|
  Fly   385 IASVTAYASGPSLAHSLSPPN 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	8/53 (15%)
		LIM2_Leupaxin	216..267	CDD:188792	6/17 (35%)
		LIM3_Leupaxin	275..327	CDD:188794
		LIM4_Paxillin_like	334..385	CDD:188725
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030