Protein Alignment LPXN and stck

DIOPT Version :10

• Sequence 1: NP_001137467.1
• Gene: LPXN / 9404
• HGNCID: 14061
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_731242.1
• Gene: stck / 40999
• FlyBaseID: FBgn0020249
• Length: 348
• Species: Drosophila melanogaster
• Alignment Length: 316
• Identity: 89/316 - (28%)
• Similarity: 127/316 - (40%)
• Gaps: 87/316 - (27%)

Human   156 HCASCQ---KPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCA 217
            ||..|.   :| ..|::::.|:.||.:.|||..|........|:|..|..||..|:|.||:|.|.
  Fly    20 HCTRCADGFEP-TEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCN 83

Human   218 YCAAPILDKVLTAMNQTWHPEHFFCSHC------------------------------------- 245
            .|...::.:|:.||:.:|||:.|.|..|
  Fly    84 KCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQK 148

Human   246 -------------GEVFGAEGFH---------------EKDKKP----------YCRKDFLAMFS 272
                         |||:  .|:|               |...:|          ||.:....|..
  Fly   149 CHGLIDEEPLRFRGEVY--HGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGI 211

Human   273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGC 337
            |.||.|.||:.|..::|:...||.|.|||..|...|.....:|..|..:||.|||...|.||..|
  Fly   212 PICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVC 276

Human   338 GQPITGRCISAMGYKFHPEHFVCAFC---LTQLSKGIFREQNDKTYCQPCFNKLFP 390
            .|.|.|...:|:...:...||.|:.|   :||.||  |.|.::|..|:.|::: ||
  Fly   277 NQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSK--FYEYDEKPVCKKCYDR-FP 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	18/55 (33%)
		LIM2_Leupaxin	216..267	CDD:188792	20/125 (16%)
		LIM3_Leupaxin	275..327	CDD:188794	20/51 (39%)
		LIM4_Paxillin_like	334..385	CDD:188725	18/53 (34%)
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	19/58 (33%)
		LIM2_PINCH	82..133	CDD:188718	11/50 (22%)
		LIM3_PINCH	146..206	CDD:188719	9/61 (15%)
		LIM4_PINCH	212..265	CDD:188720	20/52 (38%)
		LIM5_PINCH	273..326	CDD:188721	19/54 (35%)