Protein Alignment LPXN and Pax

DIOPT Version :10

• Sequence 1: NP_001137467.1
• Gene: LPXN / 9404
• HGNCID: 14061
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_523601.2
• Gene: Pax / 35215
• FlyBaseID: FBgn0041789
• Length: 581
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 192/429 - (44%)
• Similarity: 257/429 - (59%)
• Gaps: 62/429 - (14%)

Human     8 SSDALLEELERS---TLQDSDEYSNPAPLPLDQH---SRKETNLDETSEILSIQDNTSPLPAQLV 66
            |.|:||:||:.:   .:.:...:.:|.|   .:|   :.:||.    :|.|:..|.    |...|
  Fly   167 SVDSLLKELDNAHIYAVPNGSAHKSPTP---GRHVTITVRETK----TEKLTGPDG----PVGTV 220

Human    67 YTTNIQELNVYSEAQEPKESPPPSK------TSAAAQLDELMAHLTEMQAKVAVRADAGKKH--- 122
            ....:|:.:.|:    |..:.|..:      :.|..:||:|||.|::.:............|
  Fly   221 EEQIVQQKDSYT----PNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQ 281

Human   123 --------------LPDKQDHKA------------------SLDSMLGGLEQELQDLGIATVPKG 155
                          .|:|...:|                  .||||||.|:..:...|:.||.||
  Fly   282 HSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKG 346

Human   156 HCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCA 220
            .|.:|:|||.|:||.|||::||||||.|.||.:|:|:..||||.|..||..|||.|||||||||.
  Fly   347 CCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCN 411

Human   221 APILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLEN 285
            ..||||.:||:::|||.|||||:.||:.||.|||||:|.|||||.|:..||:|||.||||.::||
  Fly   412 GAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMEN 476

Human   286 YLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMG 350
            |:||:::.|||:||||.||...|..||||:.:|.|:||.|||.:||:||.||.:|||||||:||.
  Fly   477 YISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMF 541

Human   351 YKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389
            .|||||||||||||.||:||.|:||.||.||..||:|:|
  Fly   542 KKFHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIF 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	31/53 (58%)
		LIM2_Leupaxin	216..267	CDD:188792	33/50 (66%)
		LIM3_Leupaxin	275..327	CDD:188794	29/51 (57%)
		LIM4_Paxillin_like	334..385	CDD:188725	36/50 (72%)
Pax	NP_523601.2	LIM1_Paxillin_like	348..400	CDD:259830	30/51 (59%)
		LIM2_Paxillin_like	407..458	CDD:188723	33/50 (66%)
		LIM3_Paxillin_like	466..518	CDD:188724	29/51 (57%)
		LIM4_Paxillin	525..576	CDD:188795	36/50 (72%)