DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRC4B and lrrc4ba

DIOPT Version :9

Sequence 1:	NP_001073926.1	Gene:	LRRC4B / 94030	HGNCID:	25042	Length:	713	Species:	Homo sapiens
Sequence 2:	XP_021329717.1	Gene:	lrrc4ba / 556747	ZFINID:	ZDB-GENE-080327-25	Length:	729	Species:	Danio rerio

Alignment Length:	739	Identity:	488/739 - (66%)
Similarity:	545/739 - (73%)	Gaps:	125/739 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    54 ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLS 118
            |::||..||||||||||||.|:.|.|||.:|..||||||||||.||||::|||||||||||||||
Zfish    37 ASTCPAVCSCSNQASRVICARQHLEEVPDNISNNTRYLNLQENTIQVIKSDTFKHLRHLEILQLS 101

Human   119 KNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPS 183
            ||.:|:||||||||||:||||||||||||.||:||||||||||||||||||||::|.|||:||||
Zfish   102 KNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPS 166

Human   184 LRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGS 248
            ||||||||||:|:|||:|||.||:||||||||||.||||||||.||||||||||||||::|||||
Zfish   167 LRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGS 231

Human   249 FQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPW 313
            ||||.|||||||||:|::.||||||||||:|||||||||:|.||||||||||.:|||||||||||
Zfish   232 FQGLESLRKLWLMHSQMSVIERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQKLERVHLNHNPW 296

Human   314 HCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEG 378
            .|||||||||||||||||||||||||||||..|||:|||||||||||||||||||||||||||||
Zfish   297 VCNCDVLWLSWWLKETVPSNTTCCARCHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEG 361

Human   379 MAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
            ||||||||||||||||||:||||||||||||||||||||||||||||||::||||||||||||||
Zfish   362 MAAELKCRTGTSMTSVNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLRDTGQYTCMVTNSAG 426

Human   444 NTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEE--ALQP 506
            ||||:|.|||:|.|.                      |..|||||||||||:|| .|||  ||:
Zfish   427 NTTATAVLNVTAADV----------------------SVNYTYFTTVTVETVET-TGEEDSALR- 467

Human   507 RGTEKEP----PGPTTDG-VWGGGRPGDAA-----GPASSSTTAPAPRSSRPTEKAFTVPITDVT 561
              |..|.    ||||..| :|....|..|:     |.:||      ||:::||   |||||::.:
Zfish   468 --TFNETFIHIPGPTPSGHLWHEVVPTTASSLSIFGSSSS------PRATKPT---FTVPISEPS 521

Human   562 ENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPA 626
            ..:  .|||||||||||||||||||||||||||.||||||||||||||||.|.:||||||||:.|
Zfish   522 YPS--GLDDVMKTTKIIIGCFVAITFMAAVMLVVFYKLRKQHQLHKHHGPARAIEIINVEDEIGA 584

Human   627 ASAV---SVAAAAAVAS-GGGVGGDS----H---LALPALER-DHLNHHHYVAAAFKAHYSSNPS 679
            .:.:   .::..:.|.. |.|.||.|    |   :.||.|.| |||||::.     ..|:::|..
Zfish   585 GTGLRGSGISGGSTVPQIGSGGGGQSLRLHHPEIVNLPNLARADHLNHYYK-----PHHFNNNMM 644

Human   680 GGGCGGKGPPGLNS----------------------------------------IH--------- 695
            |.|.||    |||:                                        ||
Zfish   645 GLGLGG----GLNNNNNPSPCSQVQTPISCTQVPVSAGSTSCSIPSPMPLPTLGIHGSLKGLMGK 705

Human   696 ------EPLLFKSGSKENVQETQI 713
                  ||||||||||||||||||
Zfish   706 GQNPQIEPLLFKSGSKENVQETQI 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRC4B	NP_001073926.1	LRRNT	57..90	CDD:214470	22/32 (69%)
		LRR	<76..297	CDD:227223	184/220 (84%)
		LRR 1	87..108		17/20 (85%)
		leucine-rich repeat	88..111	CDD:275380	19/22 (86%)
		LRR 2	111..132		17/20 (85%)
		leucine-rich repeat	112..135	CDD:275380	19/22 (86%)
		LRR 3	135..156		17/20 (85%)
		leucine-rich repeat	136..159	CDD:275380	20/22 (91%)
		LRR 4	159..180		17/20 (85%)
		leucine-rich repeat	160..183	CDD:275380	18/22 (82%)
		LRR 5	183..205		18/21 (86%)
		leucine-rich repeat	184..208	CDD:275380	19/23 (83%)
		LRR 6	208..229		18/20 (90%)
		leucine-rich repeat	209..230	CDD:275380	18/20 (90%)
		LRR 7	230..251		18/20 (90%)
		leucine-rich repeat	231..254	CDD:275380	20/22 (91%)
		LRR 8	254..275		16/20 (80%)
		leucine-rich repeat	255..278	CDD:275380	18/22 (82%)
		LRR 9	278..299		17/20 (85%)
		leucine-rich repeat	279..300	CDD:275380	18/20 (90%)
		LRRCT	311..361	CDD:214507	45/49 (92%)
		I-set	364..453	CDD:254352	83/88 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..551		23/65 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..713		18/33 (55%)
lrrc4ba	XP_021329717.1	LRR	<60..280	CDD:227223	184/219 (84%)
		leucine-rich repeat	71..94	CDD:275380	19/22 (86%)
		leucine-rich repeat	95..118	CDD:275380	19/22 (86%)
		leucine-rich repeat	119..142	CDD:275380	20/22 (91%)
		leucine-rich repeat	143..166	CDD:275380	18/22 (82%)
		leucine-rich repeat	167..191	CDD:275380	19/23 (83%)
		leucine-rich repeat	192..213	CDD:275380	18/20 (90%)
		leucine-rich repeat	214..237	CDD:275380	20/22 (91%)
		leucine-rich repeat	238..261	CDD:275380	18/22 (82%)
		leucine-rich repeat	262..283	CDD:275380	18/20 (90%)
		TPKR_C2	294..344	CDD:326558	45/49 (92%)
		I-set	347..436	CDD:333254	83/88 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341826
Domainoid	1	1.000	180	1.000	Domainoid score	I14440
eggNOG	1	0.900	-	-		E33208_3BD40
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	888	1.000	Inparanoid score	I2910
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43169
OrthoDB	1	1.010	-	-		D140974at7742
OrthoFinder	1	1.000	-	-		FOG0001768
OrthoInspector	1	1.000	-	-		otm28139
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	1	1.100	-	-	LDO	PTHR24369
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.310