DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRAP2 and Cip4

DIOPT Version :9

Sequence 1:	NP_001278753.1	Gene:	GRAP2 / 9402	HGNCID:	4563	Length:	330	Species:	Homo sapiens
Sequence 2:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	83/396 - (20%)
Similarity:	122/396 - (30%)	Gaps:	118/396 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSR 65
            ||.:.|     :||.            ::.:|:.||.....|.|:.|..  ||.|     |.||:
  Fly   311 MEGIVK-----AGES------------INEKEDTFKVIERYQSGFTPPR--DIPF-----EDLSK 351

Human    66 ------------HQAENLL----------MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVM 108
                        :...|.|          :.|.||.|.|..|..:      |:..:...:.|..:
  Fly   352 CDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKN------SLTADGQKEDFSDL 410

Human   109 RDNK-------------GNYFLWTEKFPSLNKLVDYYRTNSI-------------SRQKQIFLRD 147
            ..|:             .|....|:....|.|:...|..||.             |..|...|:.
  Fly   411 PPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKV 475

Human   148 RTREDQGHRGNSLDRRSQ-----GGPHLSG---AVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQP 204
            ..::.||.    |::.||     ..|..|.   ..|.......|....||          |....
  Fly   476 DLKKYQGF----LEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDH----------HDDGD 526

Human   205 PQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDG----HC---GTGLGSEMNAALMHRRH- 261
            .|...|....:...:....|..:.|.....||.....|    |.   |:|.||....|:....:
  Fly   527 DQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYY 591

Human   262 -TDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTG-RLHNKL-----GL 319
             |:...|...|:   .||||.|||..:..:....||.::|::......||. |..|..     |.
  Fly   592 ETEVETLNPVGK---CRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGF 653

Human   320 FPANYV 325
            .|.:|:
  Fly   654 VPTSYI 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRAP2	NP_001278753.1	SH3_GRAP2_N	2..53	CDD:212880	10/50 (20%)
		SH2_Grb2_like	54..147	CDD:199828	25/140 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..244		20/112 (18%)
		SH3_GRAP2_C	275..327	CDD:212883	17/57 (30%)
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	3/12 (25%)
		HR1_CIP4-like	412..488	CDD:212009	14/79 (18%)
		SH3_CIP4-like	603..661	CDD:212844	17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030