DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVRL1 and sax

DIOPT Version :9

Sequence 1:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	254/508 - (50%)
Similarity:	330/508 - (64%)	Gaps:	60/508 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    35 TCESPHCKGP-----TCRGA-WCTVVLVREEGRHPQEHRGCGNLHREL---C-----------RG 79
            :||.| |:.|     ||:.| .|.....|:.....||.|||.....:|   |           :.
  Fly    81 SCEPP-CRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKR 144

Human    80 RPTEFVNHYCCDSHLCN------------HNVSLVLEATQPPSEQPGTDGQLALILGPVLALLAL 132
            ...:|||..||....||            ::|:::...|...|:      .|..:|||   .|.:
  Fly   145 NTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISK------MLVAVLGP---FLVI 200

Human   133 VALGVLGLWHVRRRQEKQRG------------LHSELGESSLILKASEQGDSMLGDLLDSDCTTG 185
            ..||.:.::.:||...|:..            ::.||      |:|:..|||.|.:.|....|:|
  Fly   201 ALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDEL------LRATSAGDSTLREYLQHSVTSG 259

Human   186 SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVL 250
            ||||||.|||||:|:||.|:||:|:|:|||||||.|||||:|||||.||||:||.||||||:|:|
  Fly   260 SGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTIL 324

Human   251 LRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHV 315
            |||:||||||.||||||||.|||||:|||:..|||:|.|.|..|..:..:.:.:|.|.||.|||.
  Fly   325 LRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHT 389

Human   316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV 380
            ||||.|||||:||||.||:|:||.||..|.|||.||||.||..:..||:||||:|||||||||||
  Fly   390 EIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEV 454

Human   381 LDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVD 445
            |||.|..:|||:.:.|||:||||||||:.||||..||.|:|:.|||||||.|||||||:||||:|
  Fly   455 LDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCID 519

Human   446 QQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEK 498
            ...|:||||.::|.:::|::::|:|||:.||..||.|||||||:.|::::.||
  Fly   520 NYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	15/26 (58%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	195/296 (66%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	24/87 (28%)
		TM_EGFR-like	182..218	CDD:213052	11/44 (25%)
		TGF_beta_GS	247..274	CDD:285687	15/26 (58%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	195/296 (66%)
		TyrKc	276..553	CDD:197581	181/276 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144581
Domainoid	1	1.000	427	1.000	Domainoid score	I603
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1347
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm41790
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890