DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVRL1 and acvrl1

DIOPT Version :9

Sequence 1:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens
Sequence 2:	XP_021325397.1	Gene:	acvrl1 / 266753	ZFINID:	ZDB-GENE-021003-1	Length:	507	Species:	Danio rerio

Alignment Length:	503	Identity:	290/503 - (57%)
Similarity:	353/503 - (70%)	Gaps:	39/503 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLMLLMALVTQG------------DPVKPSRGPLVTCTCESPH-CKGPTCRGAWCTVVLVREEGR 61
            :|.:|..||..|            ..:|.....| .|:||:.: |:..:|.|..|....|
Zfish     9 MLAVLFVLVYSGSYATTADHLMETSTLKNDESSL-QCSCENTNLCENNSCWGRICFYTSV----- 67

Human    62 HPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL-----VLEATQPPSEQPGTDGQLAL 121
            |.:..|||... .|.|.......|...||.:|.||.|:::     .|.:.:.|.       ::.|
Zfish    68 HERVVRGCFQT-AEQCYVPAIPGVYTKCCYTHHCNANLTMPEKPVCLFSVEKPI-------RVIL 124

Human   122 ILGPVLALLALVALGVLG--LWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTT 184
            ::|..|.:|.::|:...|  ||...|||.    .|....::|: ||....||...||:.|..||:
Zfish   125 LVGVPLLVLLVIAMAACGLVLWLRTRRQY----CHPVEHDTSM-LKVPSGGDPTYGDIFDEFCTS 184

Human   185 GSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTV 249
            |||:|||:|||||:|||::||||||||||||||||.|.|||||||||||||||||||||||||||
Zfish   185 GSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTV 249

Human   250 LLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLH 314
            .|||:||||||||||||:||||||||:||:||.||||||||..||:|...||:.:|.|.||.|||
Zfish   250 QLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLH 314

Human   315 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 379
            .||..|||||||||||.||||:|||.|.|||||||||||:|||.:||||:|.|||||||||||||
Zfish   315 TEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYLDVGTNPRVGTKRYMAPE 379

Human   380 VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCV 444
            ||||.||.|.|||||.|||||.|||||||.||||||||||:|||||:|:||:|||||:|||||||
Zfish   380 VLDETIRVDVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSFEEMKKVVCV 444

Human   445 DQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
            ||..|::.|||.:.|:||.:|::|:|||:.:|||||||||::|:|.|:
Zfish   445 DQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSLSKL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	16/26 (62%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	229/297 (77%)
acvrl1	XP_021325397.1	TGF_beta_GS	173..200	CDD:312125	16/26 (62%)
acvrl1	XP_021325397.1	PKc_like	196..493	CDD:328722	229/297 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20058
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	12	12.340