Protein Alignment ACVRL1 and Acvrl1

DIOPT Version :9

• Sequence 1: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_071886.1
• Gene: Acvrl1 / 25237
• RGDID: 2029
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 503
• Identity: 451/503 - (89%)
• Similarity: 470/503 - (93%)
• Gaps: 1/503 - (0%)

Human     1 MTLGSPRKGLLMLLMAL-VTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQ 64
            ||||..|:..|||.:|| :|:||.||||||.||.||||:||||.|.|:|||||||||||:|||||
  Rat     1 MTLGIFRRVFLMLSVALGLTKGDLVKPSRGQLVNCTCENPHCKRPICQGAWCTVVLVREQGRHPQ 65

Human    65 EHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLAL 129
            .:||||:|::|||.|||||||||:||....|||||||:|||||.|||:|..|..|.|||||||||
  Rat    66 VYRGCGSLNQELCLGRPTEFVNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLAL 130

Human   130 LALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLV 194
            |.|||||.||||.|||||||||||||:||||||||||||||||||||.|.|||||||||||||||
  Rat   131 LVLVALGTLGLWRVRRRQEKQRGLHSDLGESSLILKASEQGDSMLGDFLVSDCTTGSGSGLPFLV 195

Human   195 QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGF 259
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat   196 QRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGF 260

Human   260 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKP 324
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
  Rat   261 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKP 325

Human   325 AIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDC 389
            ||||||.||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
  Rat   326 AIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDC 390

Human   390 FESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNR 454
            ||||||||||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||
  Rat   391 FESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNR 455

Human   455 LAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVI 502
            |||||||||||||||||||||||||||||||||||||:|.:|||||||
  Rat   456 LAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSQNPEKPKVI 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	24/26 (92%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	290/296 (98%)
Acvrl1	NP_071886.1	Mediates specificity for BMP ligand. /evidence=ECO:0000250	74..77		0/2 (0%)
		TGF_beta_GS	174..201	CDD:400699	24/26 (92%)
		STKc_ACVR1_ALK1	197..494	CDD:271044	290/296 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83693754
Domainoid	1	1.000	581	1.000	Domainoid score	I5162
eggNOG	1	0.900	-	-		E2759_KOG2052
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20058
Inparanoid	1	1.050	925	1.000	Inparanoid score	I6113
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37587
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto142747
orthoMCL	1	0.900	-	-		OOG6_128294
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310