Protein Alignment ACVRL1 and sma-6

DIOPT Version :9

• Sequence 1: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_495271.1
• Gene: sma-6 / 174044
• WormBaseID: WBGene00004860
• Length: 636
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 184/562 - (32%)
• Similarity: 272/562 - (48%)
• Gaps: 117/562 - (20%)

Human    34 CTCESPHC-KGPTC---RGAWC----TVVLVREEGRHPQEHR-GCGNLHRELCRGRPTEFVN--- 86
            |..:...| ...||   .||.|    ..|..:.|.|....|: ||..|.    ||.....:.
 Worm    70 CNYDQSICGNNMTCVKQDGAACYHAVEEVYNKAEKRMETLHKWGCATLE----RGSGASHLTCNS 130

Human    87 ----HY------CC-DSHLCN-----------HNVSLVLEATQPPSEQPG-----TDG--QLALI 122
                |:      || :.:.||           |....:.|.|..|.:...     |.|  ...::
 Worm   131 WRAAHHSPKSIGCCYEGNYCNKNLIPPAYVHHHKEKALQEKTDNPEDYDSPLENMTRGGKMFIMV 195

Human   123 LGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASE---QGDSMLGDLLDSDCTT 184
            ...|:::.|::  |.:.|. :.|.:||.:   :.....::.||...   :..|||.|       :
 Worm   196 FATVMSVFAVI--GCIYLC-ITRAEEKSK---ARARAKTVSLKTESTYMESKSMLED-------S 247

Human   185 GSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTV 249
            |||||...|:||||.:.:.:::.:|:||||||.:.|:.|..||||.|.:.||.||..|.::|.|.
 Worm   248 GSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTN 312

Human   250 LLRHDNILGFIASDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QTLEPHLALRLAVSAACGLAH 312
            ::.|:|||.|:|:|:.| .:|.|::.|||.|||.|||.|:|.| :||....||||..|..||:.|
 Worm   313 MINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLIHSCICGIEH 377

Human   313 LHVEIFGTQG--KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
            ||..:.||..  ||.|||||.||:|::||....|||||||||:.: |....|....|.:||||||
 Worm   378 LHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRY-QNDKILPEKFNVQVGTKRY 441

Human   376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVN-------------------GIVE-- 419
            ||||::..::....|..:|..||::..||:||:|.|..||                   ||.|
 Worm   442 MAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESV 506

Human   420 --------------------------DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAAD 458
                                      .:.|||..:|.|||:|::|..|:||.:..|  |..||..
 Worm   507 SSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRP--PPDLAWK 569

Human   459 --PVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEK 498
              |.|:.|:::|.:.|:..|..|.:||::||.:.::..:|::
 Worm   570 NVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKNPDR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	13/26 (50%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	136/349 (39%)
sma-6	NP_495271.1	Activin_recp	66..157	CDD:279413	21/90 (23%)
		GS	238..265	CDD:197743	14/33 (42%)
		S_TKc	266..>473	CDD:214567	97/207 (47%)
		STKc_TGFbR_I	269..605	CDD:270958	133/338 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm15006
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750