DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVRL1 and Acvrl1

DIOPT Version :9

Sequence 1:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001264184.1	Gene:	Acvrl1 / 11482	MGIID:	1338946	Length:	517	Species:	Mus musculus

Alignment Length:	503	Identity:	446/503 - (88%)
Similarity:	468/503 - (93%)	Gaps:	3/503 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTLGSPRKGLLMLLMAL-VTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQ 64
            |||||.|:|||||.:|. :|:||..|||:  ||.|||||||||.|.|:|:|||||||||:|||||
Mouse    16 MTLGSFRRGLLMLSVAFGLTRGDLAKPSK--LVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQ 78

Human    65 EHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLAL 129
            .:||||:|::|||.||||||:||:||....|||||||:|||||.|||:|..|..|.|||||||||
Mouse    79 VYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLAL 143

Human   130 LALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLV 194
            ..|||||.||||.|||||||||.|||:|||||||||||||.||||||.|||||||||||||||||
Mouse   144 PVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLV 208

Human   195 QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGF 259
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   209 QRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGF 273

Human   260 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKP 324
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Mouse   274 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKP 338

Human   325 AIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDC 389
            ||||||.||||||||||||||||||||||||||.|||||||||||||||||||||||||.|||||
Mouse   339 AIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDC 403

Human   390 FESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNR 454
            ||||||||||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||
Mouse   404 FESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNR 468

Human   455 LAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVI 502
            |||||||||||||||||||||||||||||||||||||:|::|||||||
Mouse   469 LAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	25/26 (96%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	289/296 (98%)
Acvrl1	NP_001264184.1	LU	48..112	CDD:299177	46/63 (73%)
		TGF_beta_GS	187..214	CDD:285687	25/26 (96%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	289/296 (98%)
		Pkinase_Tyr	216..503	CDD:285015	279/286 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970433
Domainoid	1	1.000	580	1.000	Domainoid score	I5524
eggNOG	1	0.900	-	-		E2759_KOG2052
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20058
Inparanoid	1	1.050	915	1.000	Inparanoid score	I6637
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37587
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto126686
orthoMCL	1	0.900	-	-		OOG6_128294
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300