DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVRL1 and acvrl1

DIOPT Version :9

Sequence 1:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens
Sequence 2:	XP_002935162.2	Gene:	acvrl1 / 100493282	XenbaseID:	XB-GENE-484224	Length:	505	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	305/513 - (59%)
Similarity:	366/513 - (71%)	Gaps:	32/513 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     7 RKGLLMLLMALVTQG-------------DPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVV-LVR 57
            :|.:.::.:.:||..             |..|.|:  ..||.|....|.|.||.|..|.|. ...
Frog     3 QKQIWIISLVIVTSATGLGDIDQEDSLEDKTKGSK--YWTCYCNDASCSGETCVGRVCYVTESYA 65

Human    58 EEGRHPQEHRGC-GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL 121
            .|.......:|| .|..:|.|....:....| ||:...||.:  .||..|..||       .:.|
Frog    66 SESEGISRAKGCFNNSIKEHCSSLMSNLKEH-CCEWDFCNKD--KVLNVTINPS-------LVTL 120

Human   122 ILGPVL-ALLALVALGVLGLWHVR---RRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDC 182
            :|..|| :::.:|.|.::..|..:   .|:.:...:.|:..::.: ||||..|||.||:.||..|
Frog   121 LLVTVLPSVIFIVILFLVIAWIYKAKLHRRNRLLAMPSDFDDADM-LKASVVGDSTLGEFLDEYC 184

Human   183 TTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYN 247
            |||||||||||||||||||:.||||||||||||||||.|.||:||||||||||||||||||||||
Frog   185 TTGSGSGLPFLVQRTVARQITLVECVGKGRYGEVWRGTWQGENVAVKIFSSRDEQSWFRETEIYN 249

Human   248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAH 312
            ||||||:||||||||||||||||||||||||||:.|||||:|||.:::....|:||:|..|||.|
Frog   250 TVLLRHENILGFIASDMTSRNSSTQLWLITHYHDDGSLYDYLQRTSVDSEGCLKLALSIICGLVH 314

Human   313 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMA 377
            |||||||||||.||||||.||||:|||:|.|||||||||||||||..||||||||||||||||||
Frog   315 LHVEIFGTQGKAAIAHRDLKSRNILVKANKQCCIADLGLAVMHSQNGDYLDIGNNPRVGTKRYMA 379

Human   378 PEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVV 442
            ||||||.||||.|||||.||:||:|||||||.|||:|||:||||||||:||||:|||||||:|||
Frog   380 PEVLDETIRTDSFESYKQTDLWAYGLVLWEICRRTVVNGMVEDYRPPFFDVVPHDPSFEDMRKVV 444

Human   443 CVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPK 500
            |:|||.|.|.|..::|.:||.:.::|||||:.:||||||||||||||.|:.:|.::.|
Frog   445 CIDQQRPNISNTWSSDNILSAMTKIMRECWFSSPSARLTALRIKKTLNKLRSSLDQIK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	21/26 (81%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	237/296 (80%)
acvrl1	XP_002935162.2	TGF_beta_GS	175..202	CDD:369918	21/26 (81%)
acvrl1	XP_002935162.2	STKc_ACVR1_ALK1	198..494	CDD:271044	236/295 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	489	1.000	Domainoid score	I3927
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20058
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37587
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.030