Protein Alignment FOXP2 and fkh-7

DIOPT Version :10

• Sequence 1: NP_683696.2
• Gene: FOXP2 / 93986
• HGNCID: 13875
• Length: 740
• Species: Homo sapiens
• Sequence 2: NP_001023147.1
• Gene: fkh-7 / 177340
• WormBaseID: WBGene00001439
• Length: 778
• Species: Caenorhabditis elegans
• Alignment Length: 854
• Identity: 223/854 - (26%)
• Similarity: 324/854 - (37%)
• Gaps: 265/854 - (31%)

Human     5 SATETI-SNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVEL----LHLQQQQALQAARQL 64
            |:|.|: |.:|.|.:.::....|:|....:  ...|.......:|:    ||.:.....::.|.|
 Worm    17 SSTSTVTSPTSQNNHLLAEDEEQIDVVHEE--EEEDMEEMKMEIEMQSKSLHQKPSGLRRSFRPL 79

Human    65 LLQQQTSG-------------LKSPKSSDKQRPLQELLPETKLCICGHSSGDGH---PHNTFAVP 113
            :..:..||             |..|.|||.                ..:||.|:   |.:.....
 Worm    80 IASELRSGGIHKTSSDSNLKRLAGPSSSDS----------------AGTSGYGYLPRPASNLPAG 128

Human   114 VSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQ 178
            ::.......:.|.||..|:.|..:.||.....|                          .:||..
 Worm   129 INHEFKIDPLQTVQQFLQMHQSLMNSPSVPTCL--------------------------SKLLID 167

Human   179 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQ--QLV 241
            :.|...|................:...:..|.|.......|..|............:...  .|.
 Worm   168 EDQHNHQSTTTLNNVLAPPMITSESLPRPTQAQSFANSTIGGGANTSHLPVTLDTGINDNLILLA 232

Human   242 FQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMED 306
            .|::|::.||                           .:|.|:..:|:
 Worm   233 LQERLMRPQQ---------------------------PTLTQSATTPS----------------- 253

Human   307 NGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSV--LSARRDSSSHEETGA------ 363
              :.|  |...||:|::.||..::..:..|  ..:..||..:  |.|..|.:|..::.:
 Worm   254 --LSH--LAAATNSSTNATSLGSADTTRLI--QQMFLGQMLIPQLPAALDLASTIQSASMSLPLQ 312

Human   364 ----------SHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEI 418
                      .|.|:.||:|.||.|:..|:.....:.||.:||...|:|..:.|.|::.|:.:|.
 Worm   313 TTIPQPMSAPQHALWQHGMCAWPSCDQPCDSVMALITHLQHEHPPSDKSNEEMRNQIEKVESIEH 377

Human   419 QLSKERERLQAMMTHLHMRP-----------------------------------------SEPK 442
            :||.||.|||.||.||.|:|                                         |:|:
 Worm   378 KLSVERSRLQGMMQHLRMKPSPDTTTPNLVKMEAQSPLRSPKIEGAAFSIQPAQQFQQQTTSQPQ 442

Human   443 PSP------------------------KPLNLVSSVTMSKNM-------LETSPQSLPQTPTTPT 476
            .||                        .|:|.:|:|....:|       |.||.|...|..:..:
 Worm   443 VSPTSEAASSLLSIAATVAASTAAAVTSPINQISTVPSVSSMPSFLNHQLSTSSQPSSQQASGSS 507

Human   477 APVTPITQGPSVITPASVPNVGA-----IRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYAT 536
            .|:  :.:..|..:..:.||..:     .|.|.|||...|::::||.|.:||:..|||||:|||:
 Worm   508 GPL--LQRAASSASTETSPNPDSKSFVPRRSRISDKTVQPIATDIAKNRDFYRTNDVRPPYTYAS 570

Human   537 LIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVE-NVKGAVWTV 600
            |||||||||||.||||||||:|||.||||||||||||||||||||||||||.||| |||||||||
 Worm   571 LIRQAIMESSDCQLTLNEIYTWFTETFAYFRRNAATWKNAVRHNLSLHKCFQRVEQNVKGAVWTV 635

Human   601 DEVEYQKRR--------------------SQKITGSPTL-----VKNI-PTSL-GYGAALNASLQ 638
            |:.|:.:||                    .||:..:..|     ::|. |.|| |....||.:|.
 Worm   636 DDSEFYRRRPNRASATRSQPQTPLPDDISQQKLFDTSALSSFLEMQNFDPASLTGDQFQLNGNLD 700

Human   639 AALA-------ESSLPLLSNPGLINNASSGLLQA------------VHEDLNGSL----DHIDSN 680
            :.|:       .:.|.:||......|.|.|:|:.            |.|..||.|    .||...
 Worm   701 SVLSLLANADVNNPLQMLSAAAAAGNHSGGILEGQLLNNVKEEMMDVSEPHNGHLLRVARHIQKA 765

Human   681 GNSSPGCSP 689
            .......:|
 Worm   766 SKRPASANP 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXP2	NP_683696.2	FOXP-CC	367..434	CDD:465036	27/66 (41%)
		COG5025	502..>733	CDD:227358	109/239 (46%)
		FH_FOXP2	528..609	CDD:410839	69/81 (85%)
fkh-7	NP_001023147.1	FOXP-CC	326..393	CDD:465036	27/66 (41%)
		FH_FOXP2	562..644	CDD:410839	69/81 (85%)