Protein Alignment FOXP2 and foxp2

DIOPT Version :10

• Sequence 1: NP_683696.2
• Gene: FOXP2 / 93986
• HGNCID: 13875
• Length: 740
• Species: Homo sapiens
• Sequence 2: XP_012813833.2
• Gene: foxp2 / 100101742
• XenbaseID: XB-GENE-482683
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 776
• Identity: 679/776 - (87%)
• Similarity: 697/776 - (89%)
• Gaps: 68/776 - (8%)

Human     1 MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLL 65
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||::
 Frog     1 MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSSDTSSEVSTVELLHLQQQQALQAARQII 65

Human    66 LQQQTSGLKSPKSSDKQRPLQELLPETKLCICGHSSGDGHPHNTFAVPVSVAMMTPQVITPQQMQ 130
            |||||||||||||::|||.||                         ||||:||||||||||||||
 Frog    66 LQQQTSGLKSPKSNEKQRSLQ-------------------------VPVSMAMMTPQVITPQQMQ 105

Human   131 QILQQQVLSPQQLQALLQQQQAVMLQ------QQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQ 189
            ||||||||||||||||||||||||||      |||||||||||||||||||||||||||||||||
 Frog   106 QILQQQVLSPQQLQALLQQQQAVMLQQSKWFIQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQ 170

Human   190 QQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQ 254
            ||||||||||||||||||||||||.|.||||||||       |||||||||||||||||||||||
 Frog   171 QQQQQQQQQQQQQQQQQQQQQQQQPQPHPGKQAKE-------QQQLAAQQLVFQQQLLQMQQLQQ 228

Human   255 QQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTN 319
            |||||:|||||||||||.|:|||||||||||||||||||||||||||||||||||||||||||||
 Frog   229 QQHLLNLQRQGLISIPPSQSALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTN 293

Human   320 NSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICED 384
            |||||||:.||||||||||||::|||:|||||||||||||||||||||||||||||||||:||||
 Frog   294 NSSSTTSTTTSKASPPITHHSLMNGQASVLSARRDSSSHEETGASHTLYGHGVCKWPGCENICED 358

Human   385 FGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLN 449
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   359 FGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLN 423

Human   450 LVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSS 514
            |||:|||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||:
 Frog   424 LVSTVTMSKNMLETSPQSLPQTPTTPTAPVTPIAQGPSVITPASVPNVGAIRRRHSDKYNIPMST 488

Human   515 EIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRH 579
            |||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||
 Frog   489 EIAPNYEFYKNADVRPPFTYATLIRQAIMESGDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRH 553

Human   580 NLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAES 644
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
 Frog   554 NLSLHKCFVRVENVKGAVWTVDEAEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAES 618

Human   645 SLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHI---------------- 693
            |||||||.||:||||.|||||||||||||||||||||||||||||||||
 Frog   619 SLPLLSNTGLLNNASPGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHISFKFLVTPLDKRIIPV 683

Human   694 --------------HSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE 740
                          ||||||||||||:|||||||||||||||||||:|||:||||||||||
 Frog   684 PCHSTLRLLQCLQRHSIHVKEEPVIADDEDCPMSLVTTANHSPELEEDRELEEEPLSEDLE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXP2	NP_683696.2	FOXP-CC	367..434	CDD:465036	65/66 (98%)
		COG5025	502..>733	CDD:227358	221/260 (85%)
		FH_FOXP2	528..609	CDD:410839	78/80 (98%)
foxp2	XP_012813833.2	FOXP-CC	341..408	CDD:465036	65/66 (98%)
		COG5025	476..>668	CDD:227358	185/191 (97%)
		FH_FOXP2	502..583	CDD:410839	78/80 (98%)