Protein Alignment SLC22A14 and Orct

DIOPT Version :10

• Sequence 1: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 170/569 - (29%)
• Similarity: 274/569 - (48%)
• Gaps: 69/569 - (12%)

Human   130 DDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFV-----FTAQKPYCNTSWILAVGP 189
            ||...:|    ||||.:|:|:..|..:|:|:.||...|..|:     |....||.|.| |..:.|
  Fly     4 DDVITHL----GEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGS-IYELSP 63

Human   190 HLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWN---LDSIIQFGLNDTDTCQDGWIYPDAK-KRSL 250
            ||     .||:.|:....|      |..|.:.   |:..|....|:|.|| ..::|..:| ..|.
  Fly    64 HL-----WNLSYPENERCS------YYDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNSA 116

Human   251 INEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSF 315
            :.|::|||.......|:..:||.|:.:|||||..::||:||.|....||:..:|||...|....
  Fly   117 VTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPE- 180

Human   316 HLYLFFRFGISQSVVGYAISSISL-----ATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLP 375
                :|.:.||:.:||...|.:.|     |.|.:...:|..|.:....||:||.:|..|.||.:.
  Fly   181 ----YFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIH 241

Human   376 HW---QLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDEL 437
            .|   |:...:.|:|   |:.|.||:|||.|||:|||:..||..::..||..||..:|:.:.::|
  Fly   242 DWRWLQIAITLPGLL---FLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQL 303

Human   438 --QLPRKK--------VTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHF 492
              ::..||        ...|:|.|..:...|.:.||::...||..|..|:.||.....||.:...
  Fly   304 VDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLV 368

Human   493 RHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATEL 557
            ..::...:|:|.....:|.|.:.||:..|..|::.|.|..|..:|:|..     :.|
  Fly   369 NFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSD-----MNW-------- 420

Human   558 KSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSL 620
              :.:...|:.:.::.::....::::||..|||:|..|||..|:.:..|.||:  |.::.:....
  Fly   421 --LIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRP 483

Human   621 LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKE 669
            ||:.:|..|::.|..||.|||||.::|:.|::........|....:|.|
  Fly   484 LPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A14	XP_006713479.2	MFS_OAT	229..641	CDD:340932	128/432 (30%)
Orct	NP_524479.1	2A0119	11..514	CDD:273328	163/538 (30%)