Protein Alignment SLC22A14 and SLC22A

DIOPT Version :9

• Sequence 1: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 156/600 - (26%)
• Similarity: 265/600 - (44%)
• Gaps: 125/600 - (20%)

Human   137 LDAV----GEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQL 197
            |||:    |:||.||..:..|..:|.:..|  ||:..:||||           |...|....|:.
  Fly    27 LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVTYVFTA-----------ATVTHRCSVEEC 78

Human   198 NL------------TIPQAPNGSFL-TCFMY----LPVPWN----LDSIIQFGLNDTDTCQDGWI 241
            :|            :||:  ||..| :|..|    || .||    :.|...|..|......:.::
  Fly    79 DLPGSNYYEPHTNWSIPK--NGKDLDSCNRYTNSELP-QWNHSVDICSADHFTKNKEACAHNEFV 140

Human   242 YPDAKKRSLINEFDLVCGMETK-------KDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILL-S 298
            :.| .:.::.|:|.:.|..|.|       .:..|..   |:|||.    .:.|:.||..:|.| .
  Fly   141 FRD-DEVTISNDFGIFCDDEWKLSMVGTINNLGQFF---GIPIGG----FVADRYGRSFSIALGG 197

Human   299 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVG------EHRAHAIILGH 357
            :||.:: |...:|..|:..:|.|.|      :....||...:|.:::|      :.|..|..:..
  Fly   198 ILGAVL-GVIRSFSPSYGWFLVFEF------LDNMTSSTLYSTCFVIGIELVGPKRRVLACSVIT 255

Human   358 CFFAVGAVLLTGIAYSLPHWQLLFLV--GGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCY 420
            .|:|||.|||...|.:...|::|..:  |..|::  ::|.||||||.|||:.:||.:.||.:|..
  Fly   256 VFYAVGEVLLAMSAKAFHDWRILLRITYGPSLIL--LAYFWILPESVRWLLSQGKEERAKNILRR 318

Human   421 AASVNKKTIPSNLLDELQLP-RKKVTRASVLDF------------CKNRQLCKVTLVMSCVWFTV 472
            ||.|||:.:|.::||:|.|. |.|:.::|...|            ..|..||         |...
  Fly   319 AAHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLC---------WIVH 374

Human   473 SYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLF 537
            ...|:.|||.:..|....:......:::|:|.....:.::.:.||::||...:|.:.:.|:..:|
  Fly   375 VLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIF 439

Human   538 LPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLA 602
            ....:..|:|               ::.::.:.::.|:..|.:.:.:|:.||.||.:.|...|:.
  Fly   440 TGADQPVLQL---------------VLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMM 489

Human   603 SVAGAILSLTIISQTPSL------LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQI--- 658
            ...|::|:    .|||.|      .|..|....|||:..|:...|||.:..|..::..:..|
  Fly   490 GRFGSMLA----PQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVK 550

Human   659 -RNKVKDMKTKETSS 672
             ::|.||:....|::
  Fly   551 KQSKSKDLDLVVTAT 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	148/564 (26%)
		MFS	270..641	CDD:119392	105/398 (26%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	148/565 (26%)
		MFS	146..530	CDD:119392	111/427 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950