Protein Alignment SLC22A14 and CG4630

DIOPT Version :9

• Sequence 1: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 145/598 - (24%)
• Similarity: 280/598 - (46%)
• Gaps: 110/598 - (18%)

Human   133 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPHLSK-- 193
            |.::|..:||||.||:|...|..:|.:.:|....:  :||||..|  .|..       |...|
  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLS--YVFTAGSPTYRCYV-------PECDKLV 70

Human   194 -----AEQLNLTIP--QAPNGSFL--TCFMYL---------PVPWNLDSIIQ-FGLN---DTDTC 236
                 |..:::.:|  .:..|.|.  ||..::         ..||:...:.| |..|   :|:.|
  Fly    71 DAEYGANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERC 135

Human   237 QDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFM-----AGLPIGSLIFRLITDKMGRYPAIL 296
            .. ::| .:.:|:::.::.|.|    .::..::.|:     |||.:|:.:...:.|:.||....|
  Fly   136 NQ-FVY-GSSERTIVQQWGLQC----PENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFL 194

Human   297 LSLLGLIIFGFGTAFMNSFHLYLFFRF--GISQSVVGYAISSISLATEWLVGEHRAH--AIILGH 357
            ..::.:.:.|...|....:..:|||..  .:..|.| |.::.| :..| :||..:..  :|:|.:
  Fly   195 FCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGV-YPLAFI-IGVE-MVGPRKREMSSIVLNY 256

Human   358 CFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA 422
             |:|||..|| |::..||.|:.|.|...:..:..::|.|::|||.|||:.:.:.::|..::..||
  Fly   257 -FYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAA 319

Human   423 SVNKKTIPSNLL---------------------------DELQLPRKKVTRASVLDFCKNRQLCK 460
            .||::.|...|:                           |::.|..|:|.|:.:|   ..|.
  Fly   320 KVNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHIL---MGRY--- 378

Human   461 VTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTL 525
              .::..:|...:..|:.|||....|..:.:....:..::|:|........|::.||:.:|:.:|
  Fly   379 --AILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSL 441

Human   526 LQAIIWCLLLLF--LPEGEDGLRLKWPRCPATELKS---------MTILVLMLREFSLAATVTVF 579
            |...|.|:...|  |.:|:      |..| .|.::|         :.:.:.::.:..:.::..|.
  Fly   442 LLCSITCVASGFVTLAQGD------WIPC-QTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVI 499

Human   580 FLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPE 642
            :.:|||::|||:|:.|:|::|..:..||:|:  :.:::.....||:.|...|::||..||.||||
  Fly   500 YTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPE 564

Human   643 TRDQPLSESLNHS 655
            |.::.|.:::..:
  Fly   565 TFNRKLPDTVEEA 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	143/583 (25%)
		MFS	270..641	CDD:119392	103/419 (25%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	143/584 (24%)
		MFS	158..533	CDD:119392	94/394 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950