Protein Alignment SLC22A14 and CarT

DIOPT Version :9

• Sequence 1: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 142/584 - (24%)
• Similarity: 264/584 - (45%)
• Gaps: 76/584 - (13%)

Human   119 LRRLRAVHTKQ-----DDKF--ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQK 176
            |..||..|..:     |:.|  .:||..:||||.:|:.||....:|:.:...|. |.:.:|.|..
  Fly    15 LSELRQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFC-AFNQLFMADT 78

Human   177 P---YCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLT---CFMYLPVPWNLDSIIQFGLNDTDT 235
            |   :|....:|    .|...::.:|:||:..:...|.   |:.| .|.|.  .:::.|..|..|
  Fly    79 PDDYWCRIPELL----DLPLEQRKSLSIPKELDNDELVYSKCYTY-GVNWT--QLLESGEEDDLT 136

Human   236 ------------CQDGWIY-PDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITD 287
                        |..||.| ......|::.:|||||..:............|.|:|..:|.|:.|
  Fly   137 TMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLND 201

Human   288 KMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISS-------ISLATEWLV 345
            :.||..:..:.|..|:.....|:....     |:.:..|:.:||..|.:       |||.   ||
  Fly   202 RGGRRLSYFVCLATLLAGSLMTSLSKD-----FWTWAGSRVIVGLTIPAVYQIPFIISLE---LV 258

Human   346 GE-HRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKG 409
            || :|:...::...|:..|.:||:|:.|....|..|..:..:....:..|::::|||||||:|:|
  Fly   259 GENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRG 323

Human   410 KVKEAKQVLCYAASVNKKTIPSNL---------LDELQLPRKKVTRASVLDFCKNRQLCKVTLVM 465
            :::||.::|...|.||.:..|..:         .|:|:..:||:....:.|.|:...:...|:::
  Fly   324 RLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILI 388

Human   466 SCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAII 530
            :..||.....|..||.....||.:.:....:.:::|:|:.|||.:.:...||:|.|:::::...:
  Fly   389 TLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGV 453

Human   531 WCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 595
            .|::.:.||:               :....|:::.::.:..|:|:..:.:.:..||.||.:|..|
  Fly   454 ACVITVMLPD---------------DAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIG 503

Human   596 LGLVSLASVAG--AILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQ 657
            :|..|.....|  .|..:|.:.:....||:.:...|:::.......||||....|.:::....:
  Fly   504 IGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEE 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	134/546 (25%)
		MFS	270..641	CDD:119392	92/389 (24%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	134/547 (24%)
		MFS	182..551	CDD:119392	92/391 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010