Protein Alignment NRXN1 and nrxn1a

DIOPT Version :10

• Sequence 1: NP_001129131.1
• Gene: NRXN1 / 9378
• HGNCID: 8008
• Length: 1547
• Species: Homo sapiens
• Sequence 2: NP_001073490.1
• Gene: nrxn1a / 565531
• ZFINID: ZDB-GENE-070206-1
• Length: 1491
• Species: Danio rerio
• Alignment Length: 1552
• Identity: 1193/1552 - (76%)
• Similarity: 1325/1552 - (85%)
• Gaps: 78/1552 - (5%)

Human     8 RGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDD 72
            |.|..|:.:.||:. |..::|:.:||.||||||.|||.|||||||||||.:||:||.||::||||
Zfish     6 RNGAHLIWIGLLVC-CLVDMGASMEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVYFDD 69

Human    73 EGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW 137
            |||||||||:: ..|||.|.||||||||||:.:||.|||..||:|.:||.|:||||.:|: |.||
Zfish    70 EGFCDFLELLI-HNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDE-EIKW 132

Human   138 VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEV 202
            ||||||||||||||.||:||:|||||:.||:||.:::::..|:||||.::|||.|:.:.:.|..|
Zfish   133 VEVKSKRRDMTVFSHLFLGGIPPELRSVALRLTSSAIKDEVPYKGWITNLRVNGSEPVLIGSDGV 197

Human   203 KLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVL 267
            ..|          .|||..     :||||||||:|:|:.:||||.|||:|||||:|..:
Zfish   198 NSD----------ICEADH-----ICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAY------ 241

Human   268 PVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQN 332
                                       |.||||||||||||.|.:|||:||||||||||||||.|
Zfish   242 ---------------------------VGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPN 279

Human   333 PIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFND 397
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   280 PIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFND 344

Human   398 NAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPST 462
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   345 NAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPST 409

Human   463 ADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETP 527
            |||||||||||||||||||||||||||||||||||.||||||:.|||||||||||||||:|||||
Zfish   410 ADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETP 474

Human   528 ESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPR--HQKDAKHPQMIKVDFFAIEMLDGHL 590
            ||||:|.||:|||.|||||||||||||||:|||||||:  .|||.|.|:.:||||||||||||||
Zfish   475 ESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHL 539

Human   591 YLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYL 655
            ||||||||||.|.:|:.|||||||||||||||||||||||||::||||.||||||||||||:|||
Zfish   540 YLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYL 604

Human   656 GGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 720
            |||||::|||:|||||||||||||||||:||||:||||||||::||.|...|||||||||..|.|
Zfish   605 GGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAVGVKPSCSKEPPKQC 669

Human   721 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLR 785
            |||||.|:|.||:|||||||||||||||||||||:||:||||||.||||||||||||||||||||
Zfish   670 LSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLR 734

Human   786 FRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWH 850
            ||||||||:||||||::||||||||||.|||:||||||||||||.:||||||:|:|.||||||||
Zfish   735 FRSQRAYGVLMATTSQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWH 799

Human   851 TVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFN 915
            |||||||||||||.|||.|...||:.||||:|||||:||||:||:||:.:||||||||||.|:||
Zfish   800 TVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPSNFIGHLQGLSFN 864

Human   916 GMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDG 980
            ||:|||||||||||||||||..|:|:|:|||||||::||||.|.|||||.||||||||||||.||
Zfish   865 GMSYIDLCKNGDIDYCELNAMIGYRSIVADPVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDG 929

Human   981 LILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI 1045
            |||||.|||||||||||||||||||.||||||:||||:||.|||||.||||||||||:|||||||
Zfish   930 LILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI 994

Human  1046 DTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDAL 1110
            |||||||.|.||:|||||.|||:|||||:.||.||||||:||||||||||||||||||||.||||
Zfish   995 DTKITTQTTMGAKNLDLKGDLYVGGVAKDMYKDLPKLVHSKEGFQGCLASVDLNGRLPDLQSDAL 1059

Human  1111 FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI 1175
            ...||:||||||||||||||||||||||||||:||||||||||:.|||||||||||||.:.||.|
Zfish  1060 STAGQVERGCEGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLI 1124

Human  1176 TYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1240
            .|.|||||||||||||||:||||.||:||||||||||||||||:|.|.:|.|.|.||||||||.|
Zfish  1125 VYTWPPNDRPSTRADRLAVGFSTQQKDAVLVRVDSSSGLGDYLQLQIERGNIKVVFNVGTDDINI 1189

Human  1241 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEW 1305
            ||::..:||||||:|||||||||||||||..|||||||:||.|||||||||||||||||||||:|
Zfish  1190 EETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDW 1254

Human  1306 LLDKGRQLTIFNSQATIIIGGKEQG-QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGE 1369
            ||||||||||||||.||.|||.|:| :||||||||||||||||||||||.|.|:.:.|:.||||:
Zfish  1255 LLDKGRQLTIFNSQTTIKIGGWEKGSRPFQGQLSGLYYNGLKVLNMAAEGDPNVRVEGSARLVGD 1319

Human  1370 VP-SSMTTESTATAM--QSEMSTSIMETTTTLATSTARRGKPPTKEPISQTT---DDILVASAEC 1428
            :| ||:|.:|:.:|.  :||.|.||.:.|||  |::.|:||        |||   ||:|||||||
Zfish  1320 MPSSSITPQSSVSAAGNRSETSPSITDITTT--TASNRQGK--------QTTTPQDDLLVASAEC 1374

Human  1429 PSDDEDIDPCEPSSGGLANP--TRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYA 1491
            ||||||||||:|||||||:|  ..|.|   || |.||||||||||||||||||||||||||||||
Zfish  1375 PSDDEDIDPCDPSSGGLAHPPLPEAKG---YP-SPEVIRESSSTTGMVVGIVAAAALCILILLYA 1435

Human  1492 MYKYRNRDEGSYHVDESRNYISNSA-QSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
            ||||||||||||||||||||||||| |.|||.|||| |.....:.|:||||||||||
Zfish  1436 MYKYRNRDEGSYHVDESRNYISNSATQPNGAAVKEK-PIGVPKNKKDKKNKDKEYYV 1491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRXN1	NP_001129131.1	LamG	30..190	CDD:238058	107/159 (67%)
		LamG	340..486	CDD:214598	145/145 (100%)
		LamG	543..692	CDD:214598	126/150 (84%)
		EGF_CA	720..753	CDD:238011	28/32 (88%)
		Laminin_G_2	786..916	CDD:460494	103/129 (80%)
		Laminin_G_2	973..1101	CDD:460494	110/127 (87%)
		Laminin_G_2	1196..1344	CDD:460494	121/148 (82%)
		4.1m	1492..1510	CDD:128590	17/17 (100%)
nrxn1a	NP_001073490.1	LamG	27..185	CDD:238058	107/159 (67%)
		LamG	287..433	CDD:214598	145/145 (100%)
		LamG	490..641	CDD:214598	126/150 (84%)
		EGF_CA	669..702	CDD:238011	28/32 (88%)
		Laminin_G_2	735..865	CDD:460494	103/129 (80%)
		Laminin_G_2	922..1050	CDD:460494	110/127 (87%)
		Laminin_G_2	1145..1294	CDD:460494	121/148 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1318..1408		55/103 (53%)
		4.1m	1436..1454	CDD:128590	17/17 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1457..1491		22/34 (65%)