Protein Alignment NRXN1 and Nrx-IV

DIOPT Version :10

• Sequence 1: NP_001129131.1
• Gene: NRXN1 / 9378
• HGNCID: 8008
• Length: 1547
• Species: Homo sapiens
• Sequence 2: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1315
• Identity: 300/1315 - (22%)
• Similarity: 490/1315 - (37%)
• Gaps: 366/1315 - (27%)

Human   314 EYIAT---FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
            :||:.   |.|:....|||.:.||.|:.:.|...|||...||:|::: |...||..|.||:..:.
  Fly   186 DYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMV 250

Human   375 LVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTG 439
            |.::|||....:|  .|....:||.||||.::||.|               .:..|||.:: ..|
  Fly   251 LNLDLGSRVMTSL--SVGSLLDDNVWHDVVISRNQR---------------DIIFSVDRVI-VRG 297

Human   440 YTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 504
            ..|.::|.|..:...|:||.|:..:  |..|..||.|||:.:.:.:.:....:....:.|:..:.
  Fly   298 RIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLF 360

Human   505 IHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKD 569
            ......:.|.: ..:.|:||.|..||:.|..:...:..::||.|||.|..|::|       |.
  Fly   361 TRVNTIYACPS-PPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVML-------HH-- 415

Human   570 AKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLK----------KVNDGEWYHVDFQRDG 624
                     ||::    .|:|.:.|:.|...|.:|...|          :.|||:|:  .|....
  Fly   416 ---------DFYS----GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWH--SFVISI 465

Human   625 RSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 689
            ....:.:|..:.|.|.....::.........||..:|                 |:|||:|.:.:
  Fly   466 EKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKN-----------------GFVGCMRLISV 513

Human   690 DGQSKDIRQMAEVQSTAGVKPSCSKETA-------KPCLSNPCKNNGMCRDGWNRYVCDCSGTGY 747
            ||..|..:...:     |.:..|..:..       ..|..|||::.|:|......:.|||..|||
  Fly   514 DGNYKLPQDWVK-----GEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGY 573

Human   748 LGRSCEREATVLSYDGSMFMKIQLPVVMHT----------------EAEDVSLRFRSQRAYGILM 796
            .|..|......||.       :.|..|.|.                |...|:..|.|.   |.::
  Fly   574 AGAVCHTSNNPLSC-------LALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSD---GRVI 628

Human   797 ATTSRDSADTLRLE-------------LDAGRVKLTVNLD----C---IRINCNSSKGPETLF-- 839
            .|.|.....|..::             .||.::::...|:    |   :..:|.||:    ||
  Fly   629 TTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSR----LFNS 689

Human   840 ---AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAM---TGQMAG--------------------- 877
               || |.....|...|             ..|.|   .|.:.|
  Fly   690 PSEAG-NFRPFSWWISR-------------HNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNC 740

Human   878 DHTRLEFHNIETGIITERRYLSSVPSNF---------------IGHLQSLTFNGMAYIDLCKNGD 927
            |...||:.. :.|.|.|:.||......|               :|.|:            |:..|
  Fly   741 DSNSLEWME-DGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLR------------CEGDD 792

Human   928 IDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDF 992
            :          |.|:    |||:...:.:.|.......|..::.:|:||..:.:|.:.:|. .|:
  Fly   793 L----------FSNV----VTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGP-TDY 842

Human   993 IVVELVKG-YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI--- 1053
            |.:.|..| .|.:.:..|:|...:...::..||||.||.|.:.|:......| :|..|..::
  Fly   843 IKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLV-VDGSIKAEVREP 906

Human  1054 TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIER 1118
            ....|.|.|.|||.||...:           .::|:.||:.::.|||::.||       ....:|
  Fly   907 PGPVRALHLTSDLVIGATTE-----------YRDGYVGCIRALLLNGKMVDL-------KEYSKR 953

Human  1119 GCEGPST----TCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDP-GTTYIFSKGGGQITYK 1178
            |..|.||    .|:.:.|.|.|.|::::||:||||..::|.||:|.|. |...   :....|.|:
  Fly   954 GLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNL---RSSSIIRYE 1015

Human  1179 WPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNVGTDDIAIEE 1242
            :..:.| ||.|:.:.:||:|...:..|:.. ||:..|:||.:.| :.|.:...|:.|.:...|..
  Fly  1016 FEGSFR-STIAENIRVGFTTTIPKGFLLGF-SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIF 1078

Human  1243 SNAIINDGKYHVVRFTRSGGNAT--LQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEW 1305
            .......|:||.:.|.|..|.:|  |:||::..:|.    |.|.:..|.|:
  Fly  1079 PKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEY----NFDIKASADAQ-------------- 1125

Human  1306 LLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEV 1370
                      ||:...:.||..|                       :..|..:..|..|:.....
  Fly  1126 ----------FNNIQYMYIGKNE-----------------------SMTDGFVGCVSRVQFDDIY 1157

Human  1371 PSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPIS-QTTDDILVASAECPSDDED 1434
            |..:..:.........:.|.:.|....:        :|.|..||. :|....||       |:|.
  Fly  1158 PLKLMFQQNPPKNVKSLGTQLTEDFCGV--------EPVTHPPIEIETRPPPLV-------DEEK 1207

Human  1435 IDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILL-----YAMYK 1494
            :                  |:.|              ..|..::.|..|.||.||     :.:.:
  Fly  1208 L------------------RKAY--------------NEVDSVLLACLLVILFLLLILMFFLIGR 1240

Human  1495 YRNRDEGSY--HVDE 1507
            |.:|.:|.|  |.|:
  Fly  1241 YLHRHKGDYLTHEDQ 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRXN1	NP_001129131.1	LamG	30..190	CDD:238058
		LamG	340..486	CDD:214598	46/146 (32%)
		LamG	543..692	CDD:214598	35/158 (22%)
		EGF_CA	720..753	CDD:238011	13/32 (41%)
		Laminin_G_2	786..916	CDD:460494	35/193 (18%)
		Laminin_G_2	973..1101	CDD:460494	36/131 (27%)
		Laminin_G_2	1196..1344	CDD:460494	33/150 (22%)
		4.1m	1492..1510	CDD:128590	6/18 (33%)
Nrx-IV	NP_524034.2	FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058	54/167 (32%)
		LamG	376..514	CDD:238058	41/178 (23%)
		EGF	546..575	CDD:394967	12/28 (43%)
		LamG	819..943	CDD:214598	36/136 (26%)
		EGF_CA	966..998	CDD:238011	14/31 (45%)
		Laminin_G_2	1032..1156	CDD:460494	36/175 (21%)
		4.1m	1239..1255	CDD:128590	5/15 (33%)