Protein Alignment SLC22A8 and CarT

DIOPT Version :9

• Sequence 1: NP_001171661.1
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Sequence 2: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 625
• Identity: 175/625 - (28%)
• Similarity: 266/625 - (42%)
• Gaps: 111/625 - (17%)

Human     5 EILDRVGSMGHFQFLHVAILGLPI---LNMANHNLLQIFTAATPVHH-CRPPHNASTGPWVLPMG 65
            ::|..:|..|.:|.|.|..:.||.   ......|  |:|.|.||..: ||.|....     ||:.
  Fly    38 DLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFN--QLFMADTPDDYWCRIPELLD-----LPLE 95

Human    66 PNGK---PE----------RCLRF-----------------VHPPNASLPNDTQRAMEPCLDGWV 100
            ....   |:          :|..:                 ...||||.|      :..|..||.
  Fly    96 QRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWP------LIKCPQGWE 154

Human   101 YNSTK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRR-PILTCSYLLLAA 162
            ||::.  .|||.::||||:.:....:..:....|..:|..:.|.|:||.||| ....|...|||.
  Fly   155 YNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAG 219

Human   163 SGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPG 227
            | ...:.|..|..:...|.:.|..|..:.....|:::|.|....|:.::......||.|..:|.|
  Fly   220 S-LMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSG 283

Human   228 LAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK-EEGER 291
            :.|....|..|....|:||:.:||..:..|||.|||::.|:..:|||||.|:|..||:: .|...
  Fly   284 VTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVH 348

Human   292 LSLEEL----KLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT-----GFAYYSLAMG 347
            |.||..    ||..||:   ..|....:||.|.|.:|..|..::|:|||.     |.:||..|:
  Fly   349 LKLEAQIRRDKLKKQKK---KMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPAL- 409

Human   348 VEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRT 412
                |.|.|:...:...|::|:.......:...||....:.:::|.|.|.:....:|.|......
  Fly   410 ----GTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETL 470

Human   413 VLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNII 477
            ||.:..|..||:||..::.:..|||||.:|..|:|.|:....:|.:..|.:...|:....:|.:|
  Fly   471 VLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVI 535

Human   478 YGITALLGGSAALFLPETLNQPLPETIEDLE----NWSLR-----AKKPK--------------- 518
            .|..::|||...|.|||||:..||:|||:.|    ||..:     |:||:
  Fly   536 MGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLA 600

Human   519 ------QEPEVE------------KASQRIPLQPHGPGLG 540
                  .|.|:|            :..:|.||.....|.|
  Fly   601 GSSTNASEVELELRDSRRVREPAPRIDERTPLDTTASGSG 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	157/538 (29%)
		MFS	96..493	CDD:119392	124/409 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542		10/59 (17%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	157/538 (29%)
		MFS	182..551	CDD:119392	113/377 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020