Protein Alignment SLC22A8 and CG33233

DIOPT Version :9

• Sequence 1: NP_001171661.1
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Sequence 2: NP_995978.2
• Gene: CG33233 / 2769005
• FlyBaseID: FBgn0053233
• Length: 489
• Species: Drosophila melanogaster
• Alignment Length: 457
• Identity: 99/457 - (21%)
• Similarity: 180/457 - (39%)
• Gaps: 90/457 - (19%)

Human   111 EWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP- 174
            |:|   .|.|.|.:..:..:.|::..||.:|.|:||:||:.::.   |.|..:.|.:..|...|
  Fly    50 EFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIR---LALVGALSFSVISALMPD 108

Human   175 IY--MVFRFLCGFGISGI-TLSTVILN----VEWVPTRMRAIMSTALG----YCYTFGQFILP-- 226
            :|  .|.|.:.|..:|.: :|....|.    ::|.|..: ||.|.:.|    ||......|||
  Fly   109 LYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITV-AICSQSQGLALIYCPLVAMAILPNN 172

Human   227 -----GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
                 ..:|.:..||:|.:...||.::..:.....||:..:|:...:..|||..|:.:...|.||
  Fly   173 FNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKK 237

Human   287 EEGERLSLEELKLNLQKEISLAKAK-YTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGV-- 348
            .|...::|.|.|.:...:....|.. |....||..|.:.:...||.|.:   |..:.|:.:|:
  Fly   238 WEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICLFLIF---GIFFTSIGLGIWF 299

Human   349 ------EEFGVNL-----------------------------------YILQIIFGGVDVPAKFI 372
                  :..|.|.                                   .|..:.:|...:....:
  Fly   300 PVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFIL 364

Human   373 TILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSEL- 436
            ..:.:.::.|....|..:|::  .||.::   |::....||:.:|....:......:.|.||.|
  Fly   365 ASVLVHWMTRKYVIALHILIS--MILGIS---LNIMKQPTVVLIFFVLMMVLPGVLIPLATSVLV 424

Human   437 --YPTVIRQTGMGVSNLWTRVG-----SMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPE 494
              .|..:|...:.:.....|.|     :|:...:::|.:|...|.|:...|..:|    |:|.|:
  Fly   425 DCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFNIFNLCLAICVVL----AVFQPK 485

Human   495 TL 496
            .:
  Fly   486 DI 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	99/457 (22%)
		MFS	96..493	CDD:119392	98/452 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	89/415 (21%)
		MFS	23..>208	CDD:119392	43/164 (26%)
		MFS	354..>482	CDD:304372	26/136 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840