Protein Alignment TM9SF2 and TM9SF4

DIOPT Version :9

• Sequence 1: NP_004791.1
• Gene: TM9SF2 / 9375
• HGNCID: 11865
• Length: 663
• Species: Homo sapiens
• Sequence 2: NP_001285907.1
• Gene: TM9SF4 / 34778
• FlyBaseID: FBgn0028541
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 673
• Identity: 292/673 - (43%)
• Similarity: 404/673 - (60%)
• Gaps: 74/673 - (10%)

Human    15 RLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYT 79
            |..|..:||.|.|   ..:.:||:||:|||.|..::|        |::...::.|..:.|||:|.
  Fly     8 RPCLAIVLLAGVV---LVADSFYVPGVAPVEFVQDQK--------IDVKAVKMTSSRTQLPYQYY 61

Human    80 AFDFCQASEGKR--PSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFL 142
            :..||....|..  .|||||:||.|:||..:||:...|::..|:|:|.        :..:.|.:.
  Fly    62 SLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCN--------QKDRPLTWS 118

Human   143 KKSMLL---NYQH----HWIVDNMPV-TWCYDVEDGQRFCNP-------GFPIGCYITDKGHAKD 192
            |:...|   ..||    |.:|||:|| |....|.      ||       |:.:|..
  Fly   119 KEDSALVAERIQHEYFVHLLVDNLPVATRIVSVN------NPAEVTYEHGYRLGQV--------- 168

Human   193 ACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHI-------DKPDC 250
                     :.|..||.||:...:.||:......  |:|..::|..|..|..:       :.||.
  Fly   169 ---------DGDNIYINNHLKFILSYHMHSKDKY--RVVGFEVETVSVSHKELKFHGDTCNFPDS 222

Human   251 SGPPMDISNKASGEIKIAYTYSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLS 315
            :.|.:...|   ||.::.:||||.::| .|:.||||||..| .|....|.||||:||||:|.|||
  Fly   223 ARPQLVNPN---GETQLYFTYSVEWKE-SKVSWASRWDIYL-GMRDVQIHWFSIINSLVVVFFLS 282

Human   316 GMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTF 380
            |::.|||:|||.:||||||..|:.||..||.||||||||:||||:...|.|..:|||.||..|..
  Fly   283 GILTMIMIRTLRRDIARYNTDDNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMAL 347

Human   381 VTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIV 445
            :|:|||.||.|||::||||||..:.::|.:||.|||.|||.||:..|.:||....||:.|.||||
  Fly   348 ITIFFAMLGMLSPSSRGALMTSGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIV 412

Human   446 FADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQ 510
            |...|.:|..:|.:.||.|:||.|::::|.|||.|||||.::|.|.|::|...:||||||.||||
  Fly   413 FGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWFGISVPLVYLGFYLGYRKQPYQHPVRTNMIPRQ 477

Human   511 IPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATIL 575
            :|.|.:|...:...:|.||||||.:||:|||:..:||.:|.||:||||||||.|||::|::.:|:
  Fly   478 VPTQHWYMNAVLSTLMAGILPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIV 542

Human   576 LCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLF 640
            :.||.||.|||.|.||||:.||.:|||.|.|::.|||:||:||....|:||.|||.:|||.|:|.
  Fly   543 MTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLL 607

Human   641 TGTIGFFACFWFVTKIYSVVKVD 663
            ||:|||||.:.|:.:||..||:|
  Fly   608 TGSIGFFAAYVFILRIYGAVKID 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_004791.1	EMP70	75..619	CDD:367285	249/567 (44%)
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	250/568 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760