Protein Alignment ZFYVE9 and Sara

DIOPT Version :9

• Sequence 1: NP_004790.2
• Gene: ZFYVE9 / 9372
• HGNCID: 6775
• Length: 1425
• Species: Homo sapiens
• Sequence 2: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Alignment Length: 1404
• Identity: 440/1404 - (31%)
• Similarity: 672/1404 - (47%)
• Gaps: 313/1404 - (22%)

Human   154 MHNCDKRTLQNDLQDCNNYNSQSLMDAFSCSLDNENR---QTDQFSFSINESTEKDMNSEKQMDP 215
            :|...::..:|:.|...: :|:||..: |||..:...   .....|..:....|.:..||.|::|
  Fly   115 IHKFSEQASKNNGQTIVS-SSESLTTS-SCSTFSSGPSPVSNGSHSEELATPPEDEKTSEVQVEP 177

Human   216 LNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQGTDGCPA 280
            ..:.: :...|.|.......::.......|..::.::|    :|:|:       |::.||:
  Fly   178 KEQDQ-QPEQVKHEDQHQDQAVPPPTQSKQTVEELAVG----LSSIS-------ITASGTE---- 226

Human   281 VKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKP-- 343
               .::.:|:|.....:      ||      .:.|.:..:..|:.|..||.:....:||...|
  Fly   227 ---SQSLLPEEVTASSV------LG------QVLEELSEESSPSREPETEMTNGIDVPLANLPAS 276

Human   344 --DMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHEETLGTTE---FLNMTEHFSESQDMTNWK 403
              ::|                ||.|:          |:.:.|.|   .|...:|...||.:|  .
  Fly   277 VAEVP----------------VPKEM----------EQPVQTEEEDVELPQEQHPRRSQPLT--F 313

Human   404 LTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLKGTCISESEECDFSTVIDT 468
            .:.::|::|:    |.:..||....:|...|         |..:.      .:.:.|..|.|.:.
  Fly   314 CSTMDEISDT----ELDSMLQEMDADDNQAD---------DQQMP------DDEKSCSASPVTEE 359

Human   469 PAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGL 533
            .:...||:..::.......|           |:.::...:|      ::::.:......|
  Fly   360 ESVRILSDEQETTSNDQMNV-----------DNFSQASTVE------FADLKQPESTPVT----- 402

Human   534 LLNSTGDLMKKNYLHNFCS-QVPSVLGQSSPKVV--------ASLPSISVPFGGARPKQPSNLKL 589
                   .|.::...:|.| :..|:.|:.....|        |||.:.::.....||::|..|.|
  Fly   403 -------AMGEDVASSFSSTESDSLSGRKLDGEVEVDREHEDASLATDALETQEQRPQRPQTLNL 460

Human   590 QIPKPLSDHLQNDFPANSGNNTKNKN-----DILGKAKLGENSATNVCSPSLGNISNVDTNGEHL 649
                       |...|.|...::::|     :.|...::.|.:|      .:|.|...|  .|..
  Fly   461 -----------NGCQAESSTPSQDENPEIQQETLQPTEVREGAA------GVGVIPGED--DEES 506

Human   650 ESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTF 714
            ..|||                         :....|...||:|.|:||||:.|..||:|:.:||.
  Fly   507 PIYEA-------------------------VGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTM 546

Human   715 TKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASS-------- 771
            .||||||||||||.|:.|||.:.:|.:....|:||||.|:.:|...||  |.:::.|
  Fly   547 IKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA--NGLNSESAPGSALPP 609

Human   772 ---QSPNPNNPAEYCSTIPPLQQ-AQASGALSSPPPTVMVPVGVLKHPGAEVAQ---------PR 823
               :|||||||.||||||||.:| |.:.||   |||:|:|||||||......:.         .|
  Fly   610 TPIRSPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQR 671

Human   824 EQRRVWFADGILPNGEVADA-------AKLTMNGTSSAGTLAVSHDPVKPVTTSPLPAETDIC-- 879
            :::.|.|:|||.|..|:|..       :|.:..|.|.:|: .....|..|.|..| |...|..
  Fly   672 KRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGS-GAGQKPPTPATEEP-PRSIDTSST 734

Human   880 ------LFSGSI-------------TQVG------------------------SPVGSAMN--LI 899
                  ||.|||             |..|                        .|.|.|..  |.
  Fly   735 LGLVAQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDAQGCYLP 799

Human   900 PED-GLPPILIST--GVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNY---V 958
            ||: |||||.||:  |.:.||.|.....  |::.:|::   :.|.|::..|...:|||||.   :
  Fly   800 PEENGLPPICISSKEGGEVDYKVVRNDG--SLLDRLQN---ETLKFIIKNNFFVLVKIVNMSCCM 859

Human   959 NRKCWCFTTKGMHAVGQSEIVILLQC--------LPDEKCLPKDIFNHFVQLYRDA--------- 1006
            ||....|||.|:|.:|..|::|||:.        :..|..:|||:|.|..::|.:|
  Fly   860 NRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHARSGTHE 924

Human  1007 LAGNVVSNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFP 1071
            ||.....|       .:||||:|||||:::..|||.||.:::|..|||.|:||.:.|.|||||.|
  Fly   925 LAFTSPRN-------ANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLP 982

Human  1072 IRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTS 1136
            :||:|||||:||.|||||.|||.|:.::||...||:|.|.|||||.|:||.::||.:.||.|:|:
  Fly   983 LRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTT 1047

Human  1137 IKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ--NDDG----NYQTQAISIHNQPR 1195
            :.||..|..:::||:|.:::|:||....|::.||.||||:|  |||.    :|.||||:|..|||
  Fly  1048 VIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPR 1112

Human  1196 KVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEP 1260
            |:|||||||.:.|||||||...|.||||||:||||....|:.:|||||...|..|.||..||.:.
  Fly  1113 KITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDD 1177

Human  1261 Q-EHIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGS--EYKANGKVIRWTEVFFLENDDQ 1322
            | |.:.|:|||::::::.||.||||.:.|:.|:|:::...:  .|......||.::::.::.:|.
  Fly  1178 QSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDW 1242

Human  1323 H-----NCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQ 1382
            :     ||    .:.:|:.|.:|::..:||.|.|.||...|:.|||||.|||.|.|||:||:.|.
  Fly  1243 YATNGGNC----EEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGS 1303

Human  1383 PLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYIL 1421
            .||..|||.||:.|:..:||.:..:.| |:::|||||||
  Fly  1304 KLPPLYMNALDNHLIATLHGESSGIQE-PIILELIFYIL 1341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZFYVE9	NP_004790.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..255		9/53 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..352		12/64 (19%)
		FYVE_endofin	690..757	CDD:277268	36/66 (55%)
		SBD	767..823		31/76 (41%)
		SARA	773..811	CDD:314365	26/38 (68%)
		DUF3480	1048..1400	CDD:314798	173/365 (47%)
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	36/66 (55%)
		SARA	614..650	CDD:288292	26/38 (68%)
		DUF3480	959..1321	CDD:288806	173/365 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158800
Domainoid	1	1.000	332	1.000	Domainoid score	I1135
eggNOG	1	0.900	-	-		E1_KOG1841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1052
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		otm40943
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	O	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780