DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF3B and Kif3C

DIOPT Version :9

Sequence 1:	NP_004789.1	Gene:	KIF3B / 9371	HGNCID:	6320	Length:	747	Species:	Homo sapiens
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	258/700 - (36%)
Similarity:	378/700 - (54%)	Gaps:	111/700 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     7 SESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFE 71
            ||:::|||||||||..||..:...:|:::.  ..|||.||.....:. |.|.||:||:.......
  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEINE--FAVSVTNPSARISQQ-KKFIFDSVYNMKTDTEV 63

Human    72 LYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQ 136
            :|||....||:|.::|:|||||||||||.|||:||:|........|:||..|||||..||.:.|.
  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128

Human   137 QYLVRASYLEIYQEEIRDLLSKDQTKRL---ELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGN 198
            :||...:|||||.|.|||||:|::...:   .|||.|..||.|..|::....:..:....::.||
  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193

Human   199 QNRSVGATNMNEHSSRSHAIFVITIECS----EVGLDGENHIRVGKLNLVDLAGSERQAKTGAQG 259
            :||...||.||::|||||.||.||:|.|    .:|.|....|..|||:||||||||||.||||||
  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQG 258

Human   260 ERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNV 324
            :|||||::|||||||||||||:|||||:.|:|:||||||||||||||||.||:|::.:.|...:.
  Fly   259 DRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHY 323

Human   325 EETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGS 389
            :||::|||||:|||||.|||::|||||||.||::|.||..||..|
  Fly   324 DETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML-------------------- 368

Human   390 GGGGEEEEEEGEEGEEEGDDKDDYWRE-----QQEKLEIEKRAIVED------------HSLVAE 437
                    :|.::...:.:|.:...:.     |...:...|...:.|            :|::.:
  Fly   369 --------QESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTK 425

Human   438 EKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQ 502
            ....|::.||:.....|...|           :..:.|:||:.|.|        .|.|.:.:|.:
  Fly   426 PNFPLIQSKEEVQLQARSRID-----------LIKRSLIGGERIHD--------FELKEKHMARK 471

Human   503 KRREREI--------QQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQ 559
            ...:|.:        :.:.|.||    .|:..|:::.||:|||...::|...|::.::.|:.||.
  Fly   472 YAAQRHLSAIAIALSRVKCEDRD----LLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLN 532

Human   560 EEHIKERQE-LEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQ 623
            .|...:|:: |::.:| |.|::|....:...|        ..|...||.   :|.  |.|.|:|.
  Fly   533 SEFQLDREDYLDEIRN-LGRQVKFHQQLFLKF--------SSNPGKFDR---NWT--PDTILQNS 583

Human   624 ------QMMKRPVSAVGYKRPLSQ----HARMSMMIRPEARYRAENIVLL 663
                  :|.:.|.|.:....|.:|    |....::|..|.::..:|.:::
  Fly   584 LWNDDLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNNQNEIVV 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	177/338 (52%)
		Smc	<352..>614	CDD:224117	57/287 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		2/37 (5%)
		Globular	580..747		19/93 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..747
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	177/338 (52%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	173/331 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820