Protein Alignment KIF3B and Khc

DIOPT Version :10

• Sequence 1: NP_004789.1
• Gene: KIF3B / 9371
• HGNCID: 6320
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 254/787 - (32%)
• Similarity: 389/787 - (49%)
• Gaps: 141/787 - (17%)

Human     3 KLKSSESVRVVVRCRPMNGKEKAASYDKVVDV--DVKLGQVSVKNPKGTAHEMPKTFTFDAVYDW 65
            ::.:.:|::||.|.||:|..|:.|....||..  :|:...:|:..         |.:.||.|:..
  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG---------KVYLFDKVFKP 61

Human    66 NAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHI 130
            ||.|.::|:|..:.:|..||.|:||||||||||.:|||:||||:.||..|:|:||...:.||.||
  Fly    62 NASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHI 126

Human   131 -SRSQNQQYLVRASYLEIYQEEIRDLLSKDQTK-RLELKERPDTGVYVKDLSSFVTKSVKEIEHV 193
             :...|.::.::.||.|||.::|||||  |.:| .|.:.|..:...|||..:.....|.:::..|
  Fly   127 YAMEVNLEFHIKVSYYEIYMDKIRDLL--DVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEV 189

Human   194 MNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRV-GKLNLVDLAGSERQAKTGA 257
            :..|..||.:..|||||||||||::|:|.::...:    ||..:: |||.||||||||:.:||||
  Fly   190 IEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENL----ENQKKLSGKLYLVDLAGSEKVSKTGA 250

Human   258 QGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASY 322
            :|..|.||..||.||||||||||||.||..||||||||||||:||:||||||:|.:|....|||:
  Fly   251 EGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASF 315

Human   323 NVEETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQ---EEIARLKAQLEKRSIGRRKRREKR 383
            |..||.:||.:..|||.:||...|||: ..:...|.::   |:.||||.::||..|...:.|
  Fly   316 NESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWR--- 377

Human   384 REGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIE--------------KRAI------ 428
                    .||..:      .||..:.:|........||:|              :.|:
  Fly   378 --------AGETVK------AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSAS 428

Human   429 --VEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKI 491
              |.:.:.:|.|..||.::.:.|.|::.::...||.|..::.                  ||:::
  Fly   429 VAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVM------------------EQEEL 475

Human   492 LEQKRQEIAEQKRREREIQQQMESRDEETL-------ELKETYSSLQQEVDIKTKKLKKLFSKLQ 549
            :...|:|....:.....|||:.||..||..       ||...|....||:|.|.|.:..|..:||
  Fly   476 IANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQ 540

Human   550 -------AVKAEIHDLQEEHIKERQELEQTQNELTREL-KLKHLII--ENFIPLE-------EKS 597
                   |...|:..|::....:::.:.:....|.|:| ::...|.  |:.|.|:       :.|
  Fly   541 QKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDAS 605

Human   598 KI-----MNRAFFDEEEDHWK--LHPITRLENQQM-MKRPVSA----VG-YKRPLSQHARMSMMI 649
            |:     |.|.|..:.:...|  ....:.:|.||. ..:.:|.    :| |:..:|||
  Fly   606 KVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQH------- 663

Human   650 RPEARYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSK 714
              |||.::....:.|.:...||            ::..:|:.  .|:..::.|:...|..|.:.|
  Fly   664 --EARMKSLQESMREAENKKRT------------LEEQIDSL--REECAKLKAAEHVSAVNAEEK 712

Human   715 ARPKSGR 721
            .|.:..|
  Fly   713 QRAEELR 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	159/336 (47%)
		Smc	<355..>581	CDD:440809	57/265 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		6/37 (16%)
		Globular	580..747		34/165 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..747		6/23 (26%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	159/337 (47%)
		Smc	<341..>807	CDD:440809	91/437 (21%)
		Khc_CBD_cc	856..925	CDD:467880