DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NRXN3 and nrxn3

DIOPT Version :9

Sequence 1:	XP_011535665.1	Gene:	NRXN3 / 9369	HGNCID:	8010	Length:	1687	Species:	Homo sapiens
Sequence 2:	XP_031746701.1	Gene:	nrxn3 / 100379902	XenbaseID:	XB-GENE-956823	Length:	1683	Species:	Xenopus tropicalis

Alignment Length:	1699	Identity:	1442/1699 - (84%)
Similarity:	1546/1699 - (90%)	Gaps:	28/1699 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLL 65
            ||:.|||:...|::::|:.|:|||.|||||||||:|||||||||||||||||||.:||||.||||
Frog     1 MSTDLHSLSLFLRLNLLICSILGLSLGLEFMGLPSQWARYLRWDASTRSDLSFQLRTNVSAGLLL 65

Human    66 YLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQ 130
            |.||||:||||||||.||.||||||:||||||::|:|:|||..|||||:||:||||.|:||||.:
Frog    66 YFDDGGICDFLCLSLADGHVQLRFSIDCAETAIVSDKKVNDGGWHFLMLSRNRLRTTLVLDGEAK 130

Human   131 SGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQ 195
            .||::|||.:|::|||||:||||:|||..||||..|:.|..|.|.:||:||||:|||||||.|.:
Frog   131 PGEVRPQRQHMNIVSDLFVGGVPSDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRLLGSHGAR 195

Human   196 MDAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQGRSKAREE 260
            :|.||.|.|.||||||.|.||||.|||||:.|||.||.|||||:..|||:|||:.:|||||||||
Frog   196 LDLEGLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEDVNDIPGLAHLMIDDQGRSKAREE 260

Human   261 NVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINL 325
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||.|||||||||
Frog   261 NVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGKSADYVNLALKGGAVSLVINL 325

Human   326 GSGAFEAIVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSD 390
            |||||||||||.|.|||||.||:|||||||||        |||||||||||||||||||||||||
Frog   326 GSGAFEAIVEPTNDKFNDNEWHEVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSD 382

Human   391 DFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENV 455
            |||||||||||||||||||||||||||||||||||||||||||||||.||||||||:||||||||
Frog   383 DFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYGDVVFKCENV 447

Human   456 ATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFF 520
            ||||||:||:|||||||||||||||||||||||||||||||||||||||:|||.|||||||||||
Frog   448 ATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFF 512

Human   521 AVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEI 585
            |||||||:|||||||||||||||||.||||||||.||||||||||||||||::||||||||||||
Frog   513 AVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEI 577

Human   586 LDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSS 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Frog   578 LDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNAAGVKSS 642

Human   651 CSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMH 715
            |||:|.||||||||||||.|:||||||:|||||||:||||||||||||||||.||||||||:|||
Frog   643 CSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMH 707

Human   716 TEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAG 780
            |||||||.||.|||||||||||||||||||||||||||:||||||||||||||||||||||||||
Frog   708 TEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLELDGGKVKLMVNLDCIRINCNSSKGPETLYAG 772

Human   781 QKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIG 845
            ||||||||||||||||||:|||||||||||||||||||||||||||||.|||||:.|.|||||||
Frog   773 QKLNDNEWHTVRVVRRGKTLKLTVDDDVAEGTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIG 837

Human   846 HLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQ 910
            |||||||||||||||||||||||||||||||:|:||||||||:||:|||:|:|||||||||||||
Frog   838 HLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIADPVTFRTKASYLTLSTLQAYTSMHLFFQ 902

Human   911 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDN 975
            |||.|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Frog   903 FKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDN 967

Human   976 SNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRL 1040
            ||||:||||||.|||||||||||||||:||:|||.|.|||.||||||||||||||||||||||||
Frog   968 SNTHTLKVDTKAVTQVINGAKNLDLKGELYIAGLVQSMYSTLPKLVASRDGFQGCLASVDLNGRL 1032

Human  1041 PDLINDALHRSGQIERGCE---------GPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQ 1096
            ||||.||||||||||||||         ||:|||||||||||||||||||||||||||||||||.
Frog  1033 PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNH 1097

Human  1097 CNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIE 1161
            ||||||||||||||||||||||.|||||||:||||||||||||:||||||||||||.|:|||||.
Frog  1098 CNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFSTTVKEGILVRIDSAPGLMDYLQLHIV 1162

Human  1162 QGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERFQ 1226
            ||||||.||||:.||||:||..||||||||||::|||||||||||||||||||||.|||:..:
Frog  1163 QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGGNTELHQ-- 1225

Human  1227 MVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAE 1291
              |.|:|||.:|..|:..|:|||.||||||||||||||.|:||.||||||||||:||||||||||
Frog  1226 --KPKLPFKISRTPEDGQQDKGRPLTIFNTQAQIAIGGMDRGRPFQGQLSGLYYNGLKVLNMAAE 1288

Human  1292 NNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDL 1356
            .||||.|:||||||||||||.|||.|||||||||||:||||||:||||||||||:.. ...:||:
Frog  1289 PNPNINISGSVRLVGEVPSIHGTTPTTSMPPEMSTTIMETTTTLATTTTRKNRSSPG-STLTDDI 1352

Human  1357 VSSAEC--SSDDEDFVECEPSTGRSGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIE 1419
            .|||||  ||||||..:|:..||.||.|||||:||||||..|.:|||||||||||||:|||||||
Frog  1353 GSSAECFISSDDEDVTDCDTGTGTSGDELVIPVLVEDPLDIPSVATRAPSITLPPTFQPLLTIIE 1417

Human  1420 TTKDSLSMTSEAGLPCLSDQGSDGC-DDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKS 1483
            |||||.|:|.|.||||||||||||| |||||||||||||||||||||||||||||||.|||||||
Frog  1418 TTKDSQSVTPEEGLPCLSDQGSDGCDDDDGLVISGYGSGETFDSNLPPTDDEDFYTTLSLVTDKS 1482

Human  1484 LSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNR 1548
            ||||.|:||:|:.||||.||||:||||||..||:||||.|||.|.|  |||||||.:||||||:
Frog  1483 LSTSFFDGGFKSQAPKWGSKDFKPNKVSEPGRTSTTSLPPELKRST--SSSGMVPMVPAGKMNH- 1544

Human  1549 DLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTG 1613
            :||||||||||.||||||||||||:||||||||||||||||||.||.|||||||||:||||||||
Frog  1545 ELKPQPDIVLLSLPTAYELDSTKLRSPLITSPMFRNVPTANPTMPGSRRVPGASEVVRESSSTTG 1609

Human  1614 MVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQ 1678
            ||||||||||||||||||||||||||||||||||||||||:|||||||.||||||.|||..|.||
Frog  1610 MVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYITNSAQSNGALMKEKQHSSKGNHNKQ 1674

Human  1679 KNKDREYYV 1687
            ||||:||||
Frog  1675 KNKDKEYYV 1683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRXN3	XP_011535665.1	LamG	35..181	CDD:238058	103/145 (71%)
		EGF	202..232	CDD:394967	21/29 (72%)
		LamG	286..425	CDD:214598	124/138 (90%)
		LamG	482..631	CDD:214598	141/148 (95%)
		EGF_CA	659..692	CDD:238011	28/32 (88%)
		LamG	720..854	CDD:214598	125/133 (94%)
		Laminin_G_2	911..1039	CDD:396680	118/127 (93%)
		LamG	1103..1282	CDD:238058	141/178 (79%)
		Syndecan	1613..>1648	CDD:395821	34/34 (100%)
nrxn3	XP_031746701.1	LamG	27..181	CDD:238058	111/153 (73%)
		EGF	202..233	CDD:394967	22/30 (73%)
		LamG	286..417	CDD:214598	124/138 (90%)
		LamG	474..623	CDD:214598	141/148 (95%)
		EGF_CA	651..684	CDD:238011	28/32 (88%)
		LamG	712..846	CDD:214598	125/133 (94%)
		Laminin_G_2	903..1031	CDD:396680	118/127 (93%)
		LamG	1130..1279	CDD:214598	117/152 (77%)
		Syndecan	1609..>1644	CDD:395821	34/34 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	505	1.000	Domainoid score	I3658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2858	1.000	Inparanoid score	I280
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11232at32523
OrthoFinder	1	1.000	-	-		FOG0001168
OrthoInspector	1	1.000	-	-		oto151606
Panther	1	1.100	-	-	LDO	PTHR15036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160