DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHERF1 and nherf1

DIOPT Version :10

Sequence 1:NP_004243.1 Gene:NHERF1 / 9368 HGNCID:11075 Length:358 Species:Homo sapiens
Sequence 2:NP_001006751.1 Gene:nherf1 / 448423 XenbaseID:XB-GENE-487362 Length:320 Species:Xenopus tropicalis


Alignment Length:359 Identity:186/359 - (51%)
Similarity:238/359 - (66%) Gaps:56/359 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    13 RLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77
            |:|.||||.:|||||||.||.:.|||:|||||||.||||||.|||||:.|.||:|.:..||||||
 Frog     5 RVCVLEKGDSGYGFHLHSEKTRPGQYVRLVEPGSAAEKAGLRAGDRLIRVCGEDVRELGHQQVVS 69

Human    78 RIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNE---NEPRE 139
            :||||...:.|                                      ||||...|   :.|:|
 Frog    70 KIRAATEKLTL--------------------------------------EVQGVEEEVAPSSPKE 96

Human   140 ADKSHPEQ-------RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQD 197
            .:|:..:|       :||||||||:||||||:||||||||..||||:|:||||||||.:||..:|
 Frog    97 ENKATEKQPTPVLDRKELRPRLCTIKKGPSGFGFNLHSDKVHPGQFVRAVDPDSPAELAGLLPKD 161

Human   198 RIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNG 262
            |||||||:.:.||||||||:||:||||||.|||:|.|.|.:||:|.|:|.::||.||||....||
 Frog   162 RIVEVNGLNVIGKQHGDVVAAIKAGGDETSLLVLDPEADSYFKECNVVPGKQHLTGPLPEKLANG 226

Human   263 EIQK-ENSREAL-AEAALESPRPALVRSASSDTSEELNSQDSP-PKQDSTAPSSTSSSDPILDFN 324
            .::| .||.|.: .|:.|.||.||.........:::.:|:::| |..|:|:|     ::|:||.|
 Frog   227 GLEKLNNSEEQIHPESPLSSPEPAPDMVTPKLEAQKDSSENTPAPASDATSP-----TEPVLDLN 286

Human   325 ISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL 358
            :|||:||||||||||.|:||.||||||.|:||:|
 Frog   287 MSLALAKERAHQKRSQKKAPSMDWSKKKEVFSSL 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHERF1NP_004243.1 PDZ_NHERF-like 13..92 CDD:467249 51/78 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..192 44/87 (51%)
PDZ_NHERF-like 153..232 CDD:467249 60/78 (77%)
EBP50_C 235..358 CDD:462654 59/125 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..358 40/81 (49%)
nherf1NP_001006751.1 PDZ_NHERF-like 5..82 CDD:467249 51/114 (45%)
PDZ_NHERF-like 117..196 CDD:467249 60/78 (77%)
EBP50_C 199..320 CDD:462654 59/125 (47%)

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