DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHERF1 and nherf1a

DIOPT Version :10

Sequence 1:NP_004243.1 Gene:NHERF1 / 9368 HGNCID:11075 Length:358 Species:Homo sapiens
Sequence 2:NP_997872.2 Gene:nherf1a / 327272 ZFINID:ZDB-GENE-031006-7 Length:384 Species:Danio rerio


Alignment Length:393 Identity:192/393 - (48%)
Similarity:248/393 - (63%) Gaps:44/393 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGE 65
            ||:|..     |:||.||||..||||||||||.|.||:||.|||.|||..|||||||:|..||||
Zfish     1 MSSDLR-----PKLCVLEKGDTGYGFHLHGEKNKPGQFIRHVEPDSPAAAAGLLAGDKLALVNGE 60

Human    66 NVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLR-AQEAPGQAEPPAAAEVQ 129
            |||.|.|||||||||..:..:.|:|::.||.|.|.|..::.::|.:. ....|..:||....:..
Zfish    61 NVEDEKHQQVVSRIRDTVGKLELVVLNAETAELLLKHNLKCQKEYVTDGIPIPAGSEPEDEVKNG 125

Human   130 GAGNENEP-----------READKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVD 183
            .:..|:.|           |.:..|...:.|||||||.:|||.:|||||||::|:||||:||:||
Zfish   126 TSSRESTPVPETNGDMRIDRLSVSSKDSKNELRPRLCHIKKGATGYGFNLHTEKTKPGQYIRAVD 190

Human   184 PDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQ 248
            .|||||.||||.||:||:|||:.:...||.:||:||:||||||||||||.|.|.||..|.::|::
Zfish   191 EDSPAEKSGLRPQDKIVQVNGISVHTMQHSEVVAAIKAGGDETKLLVVDPEADAFFMSCEILPTE 255

Human   249 EHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSS 313
            |||.||||.|....|.:::.:.:.:.|   |.|:..:..|:|| ||...::..:|....:.||:|
Zfish   256 EHLTGPLPEPIPRREAEEQVNGKVVQE---EKPKVEMSLSSSS-TSSNTSTSAAPAPASAPAPAS 316

Human   314 -----------------------TSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELF 355
                                   .||:|..|..|:||..||||||||||:||||||||||:||||
Zfish   317 APAPASAPAPAMAAAPQEKVKEKASSADAGLALNMSLQQAKERAHQKRSNKRAPQMDWSKRNELF 381

Human   356 SNL 358
            |||
Zfish   382 SNL 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHERF1NP_004243.1 PDZ_NHERF-like 13..92 CDD:467249 54/78 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..192 38/88 (43%)
PDZ_NHERF-like 153..232 CDD:467249 54/78 (69%)
EBP50_C 235..358 CDD:462654 58/145 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..358 43/103 (42%)
nherf1aNP_997872.2 PDZ_NHERF-like 8..86 CDD:467249 53/77 (69%)
PDZ_NHERF-like 160..239 CDD:467249 54/78 (69%)
EBP50_C 242..384 CDD:462654 58/145 (40%)

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